{"doi":"10.1126/sciadv.aeb3892","title":"Swallowable expandable fibrous capsules for nonendoscopic sampling of esophageal cells","abstract":"Esophageal adenocarcinoma is a highly lethal malignancy with a 5-year survival rate of only 18.8%, largely due to late-stage diagnosis in the absence of effective population-wide screening. Survival improves to 42.9% when detected at a localized stage (I/II). More than 90% of esophageal adenocarcinoma cases are diagnosed without prior identification of Barrett's esophagus, its only known precursor. We present a swallowable, string-tethered capsule that expands in the stomach to enable atraumatic retrieval of esophageal epithelial cells without sedation or endoscopic guidance, completing the procedure in under 3 minutes. Capsules are fabricated via gas-foamed expansion of nanofiber mats or hybrid aerogel formation, enabling rapid in situ reexpansion upon gastric fluid exposure and safe retrieval. In swine studies, capsules dissolved within 2 minutes, reexpanded within seconds, required minimal retrieval force, and consistently captured intact epithelial layers without injury. This platform could enable low-cost, high-throughput esophageal sampling in primary care and resource-limited settings.","journal":"Science Advances","year":2025,"id":548518,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9441,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":861479,"name":"Huy Quang Tran","orcid":"0000-0003-0693-1351","position":1,"is_corresponding":false},{"id":1442221,"name":"Farzad Hayati","orcid":null,"position":2,"is_corresponding":false},{"id":1013926,"name":"Syed Muntazir Andrabi","orcid":"0000-0002-2998-2971","position":3,"is_corresponding":false},{"id":1241265,"name":"Zishuo Yan","orcid":"0009-0002-1727-8538","position":4,"is_corresponding":false},{"id":1243315,"name":"Imran Rather","orcid":"0000-0001-8017-7815","position":5,"is_corresponding":false},{"id":709993,"name":"Navatha Shree Sharma","orcid":"0000-0002-0085-6963","position":6,"is_corresponding":false},{"id":241267,"name":"Jingwei Xie","orcid":"0000-0002-8126-1397","position":7,"is_corresponding":false},{"id":849502,"name":"S. M. Shatil Shahriar","orcid":"0000-0002-8632-2355","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T02:53:58.530220Z","pmid":"41223281","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}