{"doi":"10.1126/sciadv.adx6350","title":"Advancing precision photothermal therapy by integrating armored gold nanostars with real-time photoacoustic thermometry and imaging","abstract":"Nanoparticle-mediated photothermal therapy (PTT) is a promising strategy for cancer treatment; however, nanoparticle instability and lack of precise imaging tools for real-time temperature monitoring during therapy and nanoparticle tracking have hindered investigations in animal models. To address these critical issues, we present a theranostic platform that seamlessly integrates armored core-gold nanostar (AC-GNS)-mediated PTT with full-view photoacoustic computed tomography (PACT), enabling nanoparticle tracking and real-time imaging-guided PTT in deep tissues. The AC-GNS platform delivered exceptional photostability and thermal resilience beyond those of conventional nanoparticles while serving as a high-performance contrast agent for PACT and a photothermal transducer for PTT. Integrating AC-GNS-mediated PTT with noninvasive PACT enabled whole-body nanoparticle tracking, PTT treatment monitoring via thermal imaging, and thermal dose determination, culminating in a 100% survival rate in a murine bladder cancer model without long-term treatment-related toxicity. This theranostic platform lays the foundation for broader research applications and provides opportunities for advancing solid tumor treatment and response assessment research.","journal":"Science Advances","year":2025,"id":512224,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9524,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":257429,"name":"Tri Vu","orcid":"0000-0002-1384-8647","position":1,"is_corresponding":false},{"id":873893,"name":"Luca Menozzi","orcid":"0000-0001-7542-1051","position":2,"is_corresponding":false},{"id":932438,"name":"Paul Klippel","orcid":null,"position":3,"is_corresponding":false},{"id":1371627,"name":"Xinrong Chen","orcid":"0000-0002-4186-0678","position":4,"is_corresponding":false},{"id":1202691,"name":"Jianing Chen","orcid":"0000-0003-1644-8662","position":5,"is_corresponding":false},{"id":1134753,"name":"Theresa Charity","orcid":null,"position":6,"is_corresponding":false},{"id":718495,"name":"Khang Hoang","orcid":null,"position":7,"is_corresponding":false},{"id":1371628,"name":"Joseph Yang","orcid":"0009-0007-4622-5757","position":8,"is_corresponding":false},{"id":673511,"name":"Yun Jing","orcid":"0000-0003-2960-5292","position":9,"is_corresponding":false},{"id":512617,"name":"Gregory M. Palmer","orcid":null,"position":10,"is_corresponding":false},{"id":257434,"name":"Junjie Yao","orcid":"0000-0002-2381-706X","position":11,"is_corresponding":false},{"id":475549,"name":"Tuan Vo‐Dinh","orcid":"0000-0003-3701-3326","position":12,"is_corresponding":false},{"id":869710,"name":"Aidan J. Canning","orcid":"0000-0002-8001-6496","position":0,"is_corresponding":true}],"reference_count":77,"raw_metadata":null,"created_at":"2026-07-19T02:48:06.263458Z","pmid":"40802759","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}