{"doi":"10.1126/sciadv.adx5687","title":"A Dapl1 <sup>+</sup> subpopulation of naïve CD8 T cells is enriched for memory-lineage precursors","abstract":"Memory CD8 T cells provide long-lasting immunity, but their developmental origins remain incompletely defined. Growing evidence suggests that functional heterogeneity exists within the naïve T cell pool, shaping lineage potential before antigen stimulation. Here, we identify a subpopulation of naïve CD8 T cells expressing death-associated protein-like 1 (Dapl1) that contains preprogrammed precursors biased toward memory differentiation. The differentiation of these precursors is independent of Dapl1 but relies on the transcription factor B-cell lymphoma/leukaemia 11b (Bcl11b), resulting in the generation of Dapl1 + central memory–like CD8 T cells after infection and stem-like memory cells in cancer. Dapl1 + naïve T cells originate among mature thymocytes and gradually appear in the periphery postnatally. Peripheral Dapl1 + and Dapl1 − populations show limited plasticity, supporting a thymic-imprinting model. These findings reveal a developmentally imprinted subset of naïve CD8 T cells committed to memory fate, uncovering an alternative pathway for memory T cell generation offering new avenues for therapeutic application.","journal":"Science Advances","year":2025,"id":542151,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9468,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":560757,"name":"Kaito A. Hioki","orcid":"0000-0003-0121-8899","position":1,"is_corresponding":false},{"id":1040478,"name":"Xueting Liang","orcid":"0000-0001-8983-2118","position":2,"is_corresponding":false},{"id":1041064,"name":"Iris Thesmar","orcid":null,"position":3,"is_corresponding":false},{"id":1431258,"name":"Julia Cernjul","orcid":null,"position":4,"is_corresponding":false},{"id":1099456,"name":"Xinjian He","orcid":"0009-0009-3681-0287","position":5,"is_corresponding":false},{"id":277984,"name":"Jesse Mager","orcid":"0000-0002-4123-0633","position":6,"is_corresponding":false},{"id":386072,"name":"Wei Cui","orcid":"0000-0001-7281-3471","position":7,"is_corresponding":false},{"id":380770,"name":"Dominique Alfandari","orcid":"0000-0002-0557-1246","position":8,"is_corresponding":false},{"id":485099,"name":"Elena L. Pobezinskaya","orcid":"0000-0001-6408-8732","position":9,"is_corresponding":false},{"id":295928,"name":"Leonid A. Pobezinsky","orcid":"0000-0002-6115-3559","position":10,"is_corresponding":false},{"id":1040477,"name":"Adam C. Lynch","orcid":"0009-0003-4518-4392","position":0,"is_corresponding":true}],"reference_count":100,"raw_metadata":null,"created_at":"2026-07-19T02:52:51.593043Z","pmid":"40845112","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}