{"doi":"10.1126/sciadv.adw6755","title":"Age-related remodeling of the sialoglycans dampens murine CD8 <sup>+</sup> T cell function","abstract":"Glycans regulate cellular function, yet how aging affects the glycocalyx remains unclear. Here, we investigate changes in immune cell glycocalyx with age and find that α2,6-linked sialic acid, a glycan epitope associated with inhibitory signaling, is down-regulated in T cells from old animals. This reduction is tightly correlated with age-associated accumulation of effector T cells, which have little to no α2,6-linked sialic acid. To understand how α2,6-linked sialic acid affects T cell physiology, we generated a mouse model with T cell–specific deletion of sialyltransferase gene St6gal1 . The lack of α2,6-linked sialic acid leads to reduced responsiveness in naïve T cells, leading to impaired T cell responses against Listeria monocytogenes infection and tumor growth. PD-1 pathway blockade partially restores St6gal1 -deficient T cells’ ability to control tumor growth. These findings suggest that α2,6-linked sialic acid is critical for maintaining long-term T cell responsiveness, and its loss may contribute to decreased T cell function with age.","journal":"Science Advances","year":2025,"id":528942,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9475,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":732271,"name":"C. Kimberly Tsui","orcid":"0000-0002-3807-5329","position":1,"is_corresponding":false},{"id":820829,"name":"Jesse Garcia Castillo","orcid":"0000-0001-5786-7914","position":2,"is_corresponding":false},{"id":1028195,"name":"Esther Jeong Yoon Kim","orcid":"0000-0003-4436-3826","position":3,"is_corresponding":false},{"id":431672,"name":"Andrea Evangelista","orcid":"0000-0003-1901-2805","position":4,"is_corresponding":false},{"id":1407192,"name":"Hengchen Liu","orcid":"0000-0001-7263-6735","position":5,"is_corresponding":false},{"id":330440,"name":"Larry Joe","orcid":null,"position":6,"is_corresponding":false},{"id":1108901,"name":"Nicholas Twells","orcid":null,"position":7,"is_corresponding":false},{"id":372451,"name":"Ellen A. Robey","orcid":"0000-0002-3630-5266","position":8,"is_corresponding":false},{"id":456104,"name":"Lara K. Mahal","orcid":"0000-0003-4791-8524","position":9,"is_corresponding":false},{"id":1014992,"name":"Michel DuPage","orcid":"0000-0002-1479-9840","position":10,"is_corresponding":false},{"id":258501,"name":"Andrew Dillin","orcid":"0000-0002-7427-2629","position":11,"is_corresponding":false},{"id":752124,"name":"Hanlin Zhang","orcid":"0000-0001-9353-6071","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T02:50:52.565868Z","pmid":"41004592","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}