{"doi":"10.1126/sciadv.ads5002","title":"Genome-wide analyses of cell-free DNA for therapeutic monitoring of patients with pancreatic cancer","abstract":"Determining response to therapy for patients with pancreatic cancer can be challenging. We evaluated methods for assessing therapeutic response using cell-free DNA (cfDNA) in plasma from patients with metastatic pancreatic cancer in the CheckPAC trial (NCT02866383). Patients were evaluated before and after initiation of therapy using tumor-informed plasma whole-genome sequencing (WGMAF) and tumor-independent genome-wide cfDNA fragmentation profiles and repeat landscapes (ARTEMIS-DELFI). Using WGMAF, molecular responders had a median overall survival (OS) of 319 days compared to 126 days for nonresponders [hazard ratio (HR) = 0.29, 95% confidence interval (CI) = 0.11–0.79, P = 0.011]. For ARTEMIS-DELFI, patients with low scores after therapy initiation had longer median OS than patients with high scores (233 versus 172 days, HR = 0.12, 95% CI = 0.046–0.31, P < 0.0001). We validated ARTEMIS-DELFI in patients with pancreatic cancer in the PACTO trial (NCT02767557). These analyses suggest that noninvasive mutation and fragmentation-based cfDNA approaches can identify therapeutic response of individuals with pancreatic cancer.","journal":"Science Advances","year":2025,"id":512135,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9177,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":240643,"name":"Daniel C. Bruhm","orcid":"0000-0002-8436-501X","position":1,"is_corresponding":false},{"id":487316,"name":"Inna M. Chen","orcid":"0000-0003-2891-0762","position":2,"is_corresponding":false},{"id":1055169,"name":"Shashikant Koul","orcid":"0000-0002-9690-7349","position":3,"is_corresponding":false},{"id":555704,"name":"Akshaya V. Annapragada","orcid":"0000-0002-9097-6511","position":4,"is_corresponding":false},{"id":550595,"name":"Nicholas A. Vulpescu","orcid":"0000-0003-1310-0257","position":5,"is_corresponding":false},{"id":1205568,"name":"Sarah Short","orcid":"0000-0003-2319-6360","position":6,"is_corresponding":false},{"id":1371013,"name":"Susann Theile","orcid":"0000-0001-9804-7744","position":7,"is_corresponding":false},{"id":844340,"name":"Kavya Boyapati","orcid":"0000-0002-1731-7480","position":8,"is_corresponding":false},{"id":420030,"name":"Bahar Alipanahi","orcid":"0000-0002-8562-8459","position":9,"is_corresponding":false},{"id":231259,"name":"Zachary L. Skidmore","orcid":"0000-0003-1928-7139","position":10,"is_corresponding":false},{"id":240636,"name":"Alessandro Leal","orcid":"0000-0001-7967-3213","position":11,"is_corresponding":false},{"id":536954,"name":"Stephen Cristiano","orcid":"0000-0002-7375-2364","position":12,"is_corresponding":false},{"id":240642,"name":"Vilmos Adleff","orcid":"0000-0002-5001-1766","position":13,"is_corresponding":false},{"id":484366,"name":"Julia S. Johansen","orcid":"0000-0002-4217-6560","position":14,"is_corresponding":false},{"id":231035,"name":"Robert B. Scharpf","orcid":"0000-0003-4702-2656","position":15,"is_corresponding":false},{"id":844339,"name":"Zachariah H. Foda","orcid":"0000-0002-3591-8482","position":16,"is_corresponding":false},{"id":240639,"name":"Jillian Phallen","orcid":"0000-0002-5492-9013","position":17,"is_corresponding":false},{"id":2257,"name":"Victor E. Velculescu","orcid":"0000-0003-1195-438X","position":18,"is_corresponding":false},{"id":240641,"name":"Carolyn Hruban","orcid":"0000-0001-9882-040X","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-19T02:48:01.269605Z","pmid":"40397745","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}