{"doi":"10.1126/sciadv.adp9150","title":"Bidirectional regulation of motor circuits using magnetogenetic gene therapy","abstract":"Here, we report a magnetogenetic system, based on a single anti-ferritin nanobody-TRPV1 receptor fusion protein, which regulated neuronal activity when exposed to magnetic fields. Adeno-associated virus (AAV)–mediated delivery of a floxed nanobody-TRPV1 into the striatum of adenosine-2a receptor–Cre drivers resulted in motor freezing when placed in a magnetic resonance imaging machine or adjacent to a transcranial magnetic stimulation device. Functional imaging and fiber photometry confirmed activation in response to magnetic fields. Expression of the same construct in the striatum of wild-type mice along with a second injection of an AAVretro expressing Cre into the globus pallidus led to similar circuit specificity and motor responses. Last, a mutation was generated to gate chloride and inhibit neuronal activity. Expression of this variant in the subthalamic nucleus in PitX2-Cre parkinsonian mice resulted in reduced c-fos expression and motor rotational behavior. These data demonstrate that magnetogenetic constructs can bidirectionally regulate activity of specific neuronal circuits noninvasively in vivo using clinically available devices.","journal":"Science Advances","year":2024,"id":427102,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9473,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":661932,"name":"Lisa E. Pomeranz","orcid":"0000-0002-8117-7355","position":1,"is_corresponding":false},{"id":871322,"name":"Roberta Marongiu","orcid":"0000-0002-7609-7000","position":2,"is_corresponding":false},{"id":470091,"name":"Xiaofei Yu","orcid":"0000-0002-1712-331X","position":3,"is_corresponding":false},{"id":1167973,"name":"Leah Kelly","orcid":null,"position":4,"is_corresponding":false},{"id":1227144,"name":"Gholamreza Hassanzadeh","orcid":"0000-0002-5213-1630","position":5,"is_corresponding":false},{"id":106394,"name":"Henrik Molina","orcid":"0000-0001-8950-4990","position":6,"is_corresponding":false},{"id":687793,"name":"George Vaisey","orcid":"0000-0002-8359-1314","position":7,"is_corresponding":false},{"id":17662,"name":"Putianqi Wang","orcid":"0009-0008-3386-9630","position":8,"is_corresponding":false},{"id":304930,"name":"Jonathan P. Dyke","orcid":"0000-0001-7170-488X","position":9,"is_corresponding":false},{"id":730095,"name":"Edward K. Fung","orcid":"0000-0002-3390-1548","position":10,"is_corresponding":false},{"id":1043000,"name":"Logan Grosenick","orcid":"0000-0003-3216-0319","position":11,"is_corresponding":false},{"id":1227145,"name":"Rick Zirkel","orcid":"0000-0003-1744-0785","position":12,"is_corresponding":false},{"id":1164256,"name":"Aldana M. Antoniazzi","orcid":"0000-0002-0728-3352","position":13,"is_corresponding":false},{"id":1227146,"name":"Sofya Norman","orcid":"0000-0002-1665-6501","position":14,"is_corresponding":false},{"id":72620,"name":"Conor Liston","orcid":"0000-0002-1639-5401","position":15,"is_corresponding":false},{"id":292521,"name":"Chris B. Schaffer","orcid":"0000-0002-7800-9596","position":16,"is_corresponding":false},{"id":292520,"name":"Nozomi Nishimura","orcid":"0000-0003-4342-9416","position":17,"is_corresponding":false},{"id":15461,"name":"Sarah A. Stanley","orcid":"0000-0002-0253-2663","position":18,"is_corresponding":false},{"id":470094,"name":"Jeffrey M. Friedman","orcid":"0000-0003-2152-0868","position":19,"is_corresponding":false},{"id":226556,"name":"Michael G. Kaplitt","orcid":"0000-0002-8979-2459","position":20,"is_corresponding":false},{"id":1164257,"name":"Santiago R. Unda","orcid":"0000-0001-7319-6794","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T01:58:47.805440Z","pmid":"39383230","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}