{"doi":"10.1126/sciadv.adp1747","title":"B cell adapter for PI 3-kinase (BCAP) coordinates antigen internalization and trafficking through the B cell receptor","abstract":"B cell adapter for PI 3-kinase (BCAP) is an adaptor molecule associated with signaling through multiple immune receptors, including the B cell receptor (BCR). However, B cell-intrinsic role of BCAP in antibody responses is unclear. We investigated the role of BCAP in B cell response to viral particles and found a previously unidentified mechanism by which BCAP regulates antigen-specific responses. B cell-specific deletion of BCAP in mice leads to decreases in antigen-specific responses through defects in BCR-antigen endocytosis. BCAP is necessary to orchestrate actin reorganization around the antigen for efficient endocytosis through BCR and intracellular processing of antigens. Therefore, loss of BCAP from B cells leads to defects in antigen endocytosis, hampering the propagation of antigen-derived signals and decreasing the ability of B cells to present antigens to T cells. Thus, our study clarifies how BCAP regulates B cell responses to complex antigens and elucidates that antigen positioning inside B cells determines different B cell activation outcomes.","journal":"Science Advances","year":2024,"id":450973,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9567,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1220411,"name":"Ursula Holder","orcid":"0000-0002-8122-7965","position":1,"is_corresponding":false},{"id":730019,"name":"Sara Sagadiev","orcid":"0000-0002-8371-0977","position":2,"is_corresponding":false},{"id":1271944,"name":"Andrea Montiel-Armendariz","orcid":null,"position":3,"is_corresponding":false},{"id":1235940,"name":"Lucy Z. Li","orcid":"0000-0003-4616-736X","position":4,"is_corresponding":false},{"id":326232,"name":"Chandrashekhar Pasare","orcid":"0000-0002-8142-2488","position":5,"is_corresponding":false},{"id":730022,"name":"Baidong Hou","orcid":"0000-0002-0892-0181","position":6,"is_corresponding":false},{"id":108914,"name":"Jessica A. Hamerman","orcid":"0000-0001-5864-5299","position":7,"is_corresponding":false},{"id":730023,"name":"Mridu Acharya","orcid":"0000-0001-7078-2560","position":8,"is_corresponding":false},{"id":948379,"name":"Jonathan Lagos","orcid":"0000-0003-4270-6813","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T02:02:28.969209Z","pmid":"39546610","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}