{"doi":"10.1126/sciadv.adn5229","title":"Macrophage-derived chemokine CCL22 establishes local LN-mediated adaptive thermogenesis and energy expenditure","abstract":"There is a regional preference around lymph nodes (LNs) for adipose beiging. Here, we show that local LN removal within inguinal white adipose tissue (iWAT) greatly impairs cold-induced beiging, and this impairment can be restored by injecting M2 macrophages or macrophage-derived C-C motif chemokine (CCL22) into iWAT. CCL22 injection into iWAT effectively promotes iWAT beiging, while blocking CCL22 with antibodies can prevent it. Mechanistically, the CCL22 receptor, C-C motif chemokine receptor 4 (CCR4), within eosinophils and its downstream focal adhesion kinase/p65/interleukin-4 signaling are essential for CCL22-mediated beige adipocyte formation. Moreover, CCL22 levels are inversely correlated with body weight and fat mass in mice and humans. Acute elevation of CCL22 levels effectively prevents diet-induced body weight and fat gain by enhancing adipose beiging. Together, our data identify the CCL22-CCR4 axis as an essential mediator for LN-controlled adaptive thermogenesis and highlight its potential to combat obesity and its associated complications.","journal":"Science Advances","year":2024,"id":438606,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1057522,"name":"Ruoci Hu","orcid":"0000-0001-6387-5611","position":1,"is_corresponding":false},{"id":1057520,"name":"Jooman Park","orcid":"0000-0001-5368-5769","position":2,"is_corresponding":false},{"id":561795,"name":"Shaolei Xiong","orcid":"0000-0003-3111-891X","position":3,"is_corresponding":false},{"id":682377,"name":"Zilai Wang","orcid":"0000-0002-1533-7728","position":4,"is_corresponding":false},{"id":1058007,"name":"Yanyu Qian","orcid":null,"position":5,"is_corresponding":false},{"id":1057521,"name":"Zuoxiao Shi","orcid":"0000-0001-7459-4559","position":6,"is_corresponding":false},{"id":1057519,"name":"Ruifan Wu","orcid":"0000-0003-4917-5197","position":7,"is_corresponding":false},{"id":1112546,"name":"Zhenbo Han","orcid":"0000-0001-6892-5163","position":8,"is_corresponding":false},{"id":259482,"name":"Sang‐Ging Ong","orcid":"0000-0003-0182-8769","position":9,"is_corresponding":false},{"id":225436,"name":"Shuhao Lin","orcid":"0000-0002-7982-746X","position":10,"is_corresponding":false},{"id":225438,"name":"Krista A Varady","orcid":"0000-0002-9279-9934","position":11,"is_corresponding":false},{"id":296397,"name":"Pingwen Xu","orcid":"0000-0001-9363-4114","position":12,"is_corresponding":false},{"id":732226,"name":"Daniel C. Berry","orcid":"0000-0002-5200-1182","position":13,"is_corresponding":false},{"id":573167,"name":"Gang Shu","orcid":null,"position":14,"is_corresponding":false},{"id":572541,"name":"Yuwei Jiang","orcid":"0000-0002-5082-8012","position":15,"is_corresponding":false},{"id":572534,"name":"Yexian Yuan","orcid":"0000-0002-9170-4227","position":0,"is_corresponding":true}],"reference_count":93,"raw_metadata":null,"created_at":"2026-07-19T02:00:43.618468Z","pmid":"38924414","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}