{"doi":"10.1126/sciadv.adl0999","title":"No replication of direct neuronal activity–related (DIANA) fMRI in anesthetized mice","abstract":"Direct imaging of neuronal activity (DIANA) by functional magnetic resonance imaging (fMRI) could be a revolutionary approach for advancing systems neuroscience research. To independently replicate this observation, we performed fMRI experiments in anesthetized mice. The blood oxygenation level-dependent (BOLD) response to whisker stimulation was reliably detected in the primary barrel cortex before and after DIANA experiments; however, no DIANA-like fMRI peak was observed in individual animals' data with the 50 to 300 trials. Extensively averaged data involving 1050 trials in six mice showed a flat baseline and no detectable neuronal activity-like fMRI peak. However, spurious, nonreplicable peaks were found when using a small number of trials, and artifactual peaks were detected when some outlier-like trials were excluded. Further, no detectable DIANA peak was observed in the BOLD-responding thalamus from the selected trials with the neuronal activity-like reference function in the barrel cortex. Thus, we were unable to replicate the previously reported results without data preselection.","journal":"Science Advances","year":2024,"id":431022,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9624,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1028141,"name":"Geun Ho Im","orcid":"0009-0001-5751-6951","position":1,"is_corresponding":false},{"id":575981,"name":"Sangcheon Choi","orcid":"0000-0001-7327-1344","position":2,"is_corresponding":false},{"id":251801,"name":"Xin Yu","orcid":"0000-0001-9890-5489","position":3,"is_corresponding":false},{"id":235871,"name":"Peter A. Bandettini","orcid":"0000-0001-9038-4746","position":4,"is_corresponding":false},{"id":268791,"name":"Ravi S. Menon","orcid":"0000-0002-7916-0263","position":5,"is_corresponding":false},{"id":414050,"name":"Seong‐Gi Kim","orcid":"0000-0003-1960-4464","position":6,"is_corresponding":false},{"id":802029,"name":"Sang‐Han Choi","orcid":"0000-0002-4622-3651","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T01:59:25.642507Z","pmid":"38536912","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}