{"doi":"10.1126/sciadv.adl0885","title":"Tungsten-anisole complex provides 3,6-substituted cyclohexenes for highly diversified chemical libraries","abstract":"Medicinal chemists use vast combinatorial molecular libraries to develop leads for new pharmaceuticals. The syntheses of these compounds typically rely on coupling molecular fragments through atoms with planar (sp 2 ) geometry. These so-called flat molecules often lack the protein binding site specificity needed to be an effective drug. Here, we demonstrate a coupling strategy in which a cyclohexene is used as a linker to connect two diverse molecular fragments while forming two new tetrahedral (sp 3 ) stereocenters. These connections are made with the aid of a tungsten complex that activates anisole toward an unusual double protonation, followed by sequential nucleophilic additions. As a result, either cis- or trans-disubstituted cyclohexenes can be prepared with a range of chemical diversity unparalleled by other dearomatization methods.","journal":"Science Advances","year":2024,"id":428507,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9512,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1110036,"name":"Jeremy M. Bloch","orcid":"0000-0002-9372-714X","position":1,"is_corresponding":false},{"id":274551,"name":"Jacob A. Smith","orcid":"0000-0003-1008-1476","position":2,"is_corresponding":false},{"id":1110037,"name":"Megan N. Ericson","orcid":"0000-0002-1871-1252","position":3,"is_corresponding":false},{"id":1230144,"name":"Daniel J. Siela","orcid":"0009-0002-8999-8964","position":4,"is_corresponding":false},{"id":1230145,"name":"Mason R. Ortiz","orcid":"0009-0002-1058-2836","position":5,"is_corresponding":false},{"id":1230661,"name":"Mary H. Shingler","orcid":null,"position":6,"is_corresponding":false},{"id":1230146,"name":"Sarah Fong","orcid":"0009-0007-1390-7698","position":7,"is_corresponding":false},{"id":1230147,"name":"Jonathan Laredo","orcid":"0009-0006-6168-0486","position":8,"is_corresponding":false},{"id":1230148,"name":"Ishaan U. Patel","orcid":"0009-0009-2465-0749","position":9,"is_corresponding":false},{"id":1230149,"name":"Matt McGraw","orcid":"0009-0002-5870-5049","position":10,"is_corresponding":false},{"id":274556,"name":"Diane A. Dickie","orcid":"0000-0003-0939-3309","position":11,"is_corresponding":false},{"id":274559,"name":"W. Dean Harman","orcid":"0000-0003-0939-6980","position":12,"is_corresponding":false},{"id":1110035,"name":"Justin T. Weatherford-Pratt","orcid":"0000-0002-9951-2748","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T01:59:02.165535Z","pmid":"38363845","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}