{"doi":"10.1126/sciadv.adj7481","title":"Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolites","abstract":"Exercise promotes pulsatile shear stress in the arterial circulation and ameliorates cardiometabolic diseases. However, exercise-mediated metabolic transducers for vascular protection remain under-investigated. Untargeted metabolomic analysis demonstrated that wild-type mice undergoing voluntary wheel running exercise expressed increased endothelial stearoyl-CoA desaturase 1 (SCD1) that catalyzes anti-inflammatory lipid metabolites, namely, oleic (OA) and palmitoleic acids (PA), to mitigate NF-κB–mediated inflammatory responses. In silico analysis revealed that exercise augmented time-averaged wall shear stress but mitigated flow recirculation and oscillatory shear index in the lesser curvature of the mouse aortic arch. Following exercise, endothelial Scd1 –deleted mice ( Ldlr −/− Scd1 EC−/− ) on high-fat diet developed persistent VCAM1-positive endothelium in the lesser curvature and the descending aorta, whereas SCD1 overexpression via adenovirus transfection mitigated endoplasmic reticulum stress and inflammatory biomarkers. Single-cell transcriptomics of the aorta identified Scd1 -positive and Vcam1 -negative endothelial subclusters interacting with other candidate genes. Thus, exercise mitigates flow recirculation and activates endothelial SCD1 to catalyze OA and PA for vascular endothelial protection.","journal":"Science Advances","year":2024,"id":424064,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9576,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":584468,"name":"Mehrdad Roustaei","orcid":"0000-0001-5765-3879","position":1,"is_corresponding":false},{"id":704718,"name":"Sandro Satta","orcid":"0000-0002-0827-8862","position":2,"is_corresponding":false},{"id":700533,"name":"Jae Min Cho","orcid":"0000-0002-4461-6945","position":3,"is_corresponding":false},{"id":1220396,"name":"Henry Phan","orcid":"0009-0009-2602-0783","position":4,"is_corresponding":false},{"id":385043,"name":"Kyung In Baek","orcid":"0000-0001-9388-2070","position":5,"is_corresponding":false},{"id":748316,"name":"Ana M. Blázquez‐Medela","orcid":"0000-0003-3829-6997","position":6,"is_corresponding":false},{"id":1101144,"name":"Sheila Gonzalez-Ramos","orcid":"0000-0001-7065-4884","position":7,"is_corresponding":false},{"id":824015,"name":"Khoa Vu","orcid":"0009-0007-9224-2179","position":8,"is_corresponding":false},{"id":1101145,"name":"Seulki Park","orcid":"0009-0006-5679-3718","position":9,"is_corresponding":false},{"id":244612,"name":"Tomohiro Yokota","orcid":"0000-0003-2540-3810","position":10,"is_corresponding":false},{"id":264478,"name":"Jennifer A. Sumner","orcid":"0000-0002-0217-7171","position":11,"is_corresponding":false},{"id":564715,"name":"Julia J. Mack","orcid":"0000-0002-9239-8436","position":12,"is_corresponding":false},{"id":446759,"name":"Curt D. Sigmund","orcid":"0000-0002-1453-0921","position":13,"is_corresponding":false},{"id":414530,"name":"Srinivasa T. Reddy","orcid":"0000-0003-2959-9531","position":14,"is_corresponding":false},{"id":390312,"name":"Rongsong Li","orcid":"0000-0002-8247-5258","position":15,"is_corresponding":false},{"id":385049,"name":"Tzung K. Hsiai","orcid":"0000-0003-1734-0792","position":16,"is_corresponding":false},{"id":564716,"name":"Susana Cavallero","orcid":"0000-0001-5402-8840","position":0,"is_corresponding":true}],"reference_count":100,"raw_metadata":null,"created_at":"2026-07-19T01:58:07.191194Z","pmid":"38354249","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}