{"doi":"10.1126/sciadv.adj4387","title":"Chemosensory detection of polyamine metabolites guides\n            <i>C. elegans</i>\n            to nutritive microbes","abstract":"<jats:p>\n            Much is known about molecular mechanisms by which animals detect pathogenic microbes, but how animals sense beneficial microbes remains poorly understood. The roundworm\n            <jats:italic>Caenorhabditis elegans</jats:italic>\n            is a microbivore that must distinguish nutritive microbes from pathogens. We characterized a neural circuit used by\n            <jats:italic>C. elegans</jats:italic>\n            to rapidly discriminate between nutritive bacteria and pathogens. Distinct sensory neuron populations responded to chemical cues from nutritive\n            <jats:italic>Escherichia coli</jats:italic>\n            and pathogenic\n            <jats:italic>Enterococcus faecalis</jats:italic>\n            , and these neural signals are decoded by downstream AIB interneurons. The polyamine metabolites cadaverine, putrescine, and spermidine produced by\n            <jats:italic>E. coli</jats:italic>\n            activate this neural circuit and elicit positive chemotaxis. Our study shows how polyamine odorants can be sensed by animals as proxies for microbe identity and suggests that, hence, polyamines might have widespread roles brokering host-microbe interactions.\n          </jats:p>","journal":"Science Advances","year":2024,"id":648860,"datarank":0.5928093191907745,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.1592535555063498,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.1592535555063498,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":15,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1691233,"name":"Lia Ficaro","orcid":null,"position":1,"is_corresponding":false},{"id":675058,"name":"Chenguang Li","orcid":"0000-0003-2884-6414","position":2,"is_corresponding":false},{"id":236060,"name":"Drew R. Jones","orcid":"0000-0001-8732-9818","position":3,"is_corresponding":false},{"id":86966,"name":"Sharad Ramanathan","orcid":"0000-0001-9445-1248","position":4,"is_corresponding":false},{"id":364200,"name":"Niels Ringstad","orcid":"0000-0002-8679-2269","position":5,"is_corresponding":false},{"id":1085986,"name":"Benjamin Brissette","orcid":"0000-0002-8652-5208","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Chemosensory detection of polyamine metabolites guides\n            <i>C. elegans</i>\n            to nutritive microbes","abstract":"<jats:p>\n            Much is known about molecular mechanisms by which animals detect pathogenic microbes, but how animals sense beneficial microbes remains poorly understood. The roundworm\n            <jats:italic>Caenorhabditis elegans</jats:italic>\n            is a microbivore that must distinguish nutritive microbes from pathogens. We characterized a neural circuit used by\n            <jats:italic>C. elegans</jats:italic>\n            to rapidly discriminate between nutritive bacteria and pathogens. Distinct sensory neuron populations responded to chemical cues from nutritive\n            <jats:italic>Escherichia coli</jats:italic>\n            and pathogenic\n            <jats:italic>Enterococcus faecalis</jats:italic>\n            , and these neural signals are decoded by downstream AIB interneurons. The polyamine metabolites cadaverine, putrescine, and spermidine produced by\n            <jats:italic>E. coli</jats:italic>\n            activate this neural circuit and elicit positive chemotaxis. Our study shows how polyamine odorants can be sensed by animals as proxies for microbe identity and suggests that, hence, polyamines might have widespread roles brokering host-microbe interactions.\n          </jats:p>","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38517971","pmcid":"PMC10959419","openalex_id":"https://openalex.org/W4393079281","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS117908","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R35 GM122573","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM008313","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"T32 NS086750","title":null},{"funder_name":"NIDCD NIH HHS","grant_id":"F31 DC019045","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01NS117908-04","title":"Mechanisms of Synaptic Dopamine Signaling in the Control of Behavior"},{"funder_name":"National Institutes of Health","grant_id":"5R35GM122573-07","title":"Molecular genetics of sensory modulation of motor programs"},{"funder_name":"National Institutes of Health","grant_id":"5F31DC019045-02","title":"Neural and molecular mechanisms of microbe-sensing in the control of animal behavior - Resubmission - 1"},{"funder_name":"National Institutes of Health","grant_id":"5T32NS086750-04","title":"Training Program in Molecular, Cellular, and Translational Neuroscience"},{"funder_name":"National Institutes of Health","grant_id":"1F32GM013039-01","title":"MOLECULAR ANALYSIS OF THE YEAST HEAT SHOCK TRANSCRIPTION"}],"total_grants":10,"fwci":2.8085,"citation_percentile":0.91894852,"influential_citations":0,"citation_trend":[{"year":2024,"count":2},{"year":2025,"count":13},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/sciadv.adj4387?download=true","host_type":"journal"},{"url":"https://www.science.org/doi/pdf/10.1126/sciadv.adj4387?download=true","host_type":"publisher"},{"url":"https://www.science.org/doi/pdf/10.1126/sciadv.adj4387","host_type":"publisher"},{"url":"https://doi.org/10.1126/sciadv.adj4387","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38517971","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10959419","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10959419?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1126/sciadv.adj4387","host_type":""}],"fields_of_study":["Genetics, Aging, and Longevity in Model Organisms","Circadian rhythm and melatonin","Neuroendocrine regulation and behavior","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Polyamines","Caenorhabditis elegans","Escherichia coli","Spermidine","Putrescine"],"mesh_terms":["Animals","Escherichia coli","Polyamines","Putrescine","Spermidine","Caenorhabditis elegans"],"keywords":["Putrescine","Spermidine","Cadaverine","Polyamine","Caenorhabditis elegans","Biology","Chemotaxis","Enterococcus faecalis","Escherichia coli","Spermine","Bacteria","Microbiology","Biochemistry","Genetics","Gene","Enzyme","Polyamines","Animals","Neuroscience"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Reduced inequalities"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T03:03:11.480753Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}