{"doi":"10.1126/sciadv.adh9570","title":"Leptin receptor neurons in the dorsomedial hypothalamus input to the circadian feeding network","abstract":"<jats:p>\n            Salient cues, such as the rising sun or availability of food, entrain biological clocks for behavioral adaptation. The mechanisms underlying entrainment to food availability remain elusive. Using single-nucleus RNA sequencing during scheduled feeding, we identified a dorsomedial hypothalamus leptin receptor–expressing (DMH\n            <jats:sup>LepR</jats:sup>\n            ) neuron population that up-regulates circadian entrainment genes and exhibits calcium activity before an anticipated meal. Exogenous leptin, silencing, or chemogenetic stimulation of DMH\n            <jats:sup>LepR</jats:sup>\n            neurons disrupts the development of molecular and behavioral food entrainment. Repetitive DMH\n            <jats:sup>LepR</jats:sup>\n            neuron activation leads to the partitioning of a secondary bout of circadian locomotor activity that is in phase with the stimulation and dependent on an intact suprachiasmatic nucleus (SCN). Last, we found a DMH\n            <jats:sup>LepR</jats:sup>\n            neuron subpopulation that projects to the SCN with the capacity to influence the phase of the circadian clock. This direct DMH\n            <jats:sup>LepR</jats:sup>\n            -SCN connection is well situated to integrate the metabolic and circadian systems, facilitating mealtime anticipation.\n          </jats:p>","journal":"Science Advances","year":2023,"id":654769,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":877305,"name":"Elizabeth Godschall","orcid":"0000-0002-9719-5048","position":1,"is_corresponding":false},{"id":877945,"name":"Charles D. Brennan","orcid":null,"position":2,"is_corresponding":false},{"id":1180874,"name":"Qi Zhang","orcid":"0000-0002-5195-511X","position":3,"is_corresponding":false},{"id":1708918,"name":"Ruei-Jen Abraham-Fan","orcid":null,"position":4,"is_corresponding":false},{"id":1708919,"name":"Sydney P. Williams","orcid":null,"position":5,"is_corresponding":false},{"id":1483077,"name":"Taha Buğra Güngül","orcid":"0000-0001-7632-4456","position":6,"is_corresponding":false},{"id":1164308,"name":"Roberta Onoharigho","orcid":"0000-0002-7321-6369","position":7,"is_corresponding":false},{"id":1708921,"name":"Aleyna Buyukaksakal","orcid":"0009-0004-5970-1001","position":8,"is_corresponding":false},{"id":1708923,"name":"Ricardo Salinas","orcid":"0009-0009-2569-3791","position":9,"is_corresponding":false},{"id":1708925,"name":"Isabelle R. Sajonia","orcid":null,"position":10,"is_corresponding":false},{"id":1708926,"name":"Joey J. Olivieri","orcid":null,"position":11,"is_corresponding":false},{"id":896135,"name":"O. Yipkin Calhan","orcid":"0000-0001-5630-6533","position":12,"is_corresponding":false},{"id":411670,"name":"Christopher D. Deppmann","orcid":"0000-0002-6591-1767","position":13,"is_corresponding":false},{"id":258936,"name":"John N. Campbell","orcid":"0000-0002-3943-8312","position":14,"is_corresponding":false},{"id":411664,"name":"Brandon Podyma","orcid":"0000-0002-0849-8726","position":15,"is_corresponding":false},{"id":411671,"name":"Ali D. Güler","orcid":"0000-0001-8218-850X","position":16,"is_corresponding":false},{"id":877303,"name":"Qijun Tang","orcid":"0000-0002-5958-4616","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Leptin receptor neurons in the dorsomedial hypothalamus input to the circadian feeding network","abstract":"<jats:p>\n            Salient cues, such as the rising sun or availability of food, entrain biological clocks for behavioral adaptation. The mechanisms underlying entrainment to food availability remain elusive. Using single-nucleus RNA sequencing during scheduled feeding, we identified a dorsomedial hypothalamus leptin receptor–expressing (DMH\n            <jats:sup>LepR</jats:sup>\n            ) neuron population that up-regulates circadian entrainment genes and exhibits calcium activity before an anticipated meal. Exogenous leptin, silencing, or chemogenetic stimulation of DMH\n            <jats:sup>LepR</jats:sup>\n            neurons disrupts the development of molecular and behavioral food entrainment. Repetitive DMH\n            <jats:sup>LepR</jats:sup>\n            neuron activation leads to the partitioning of a secondary bout of circadian locomotor activity that is in phase with the stimulation and dependent on an intact suprachiasmatic nucleus (SCN). Last, we found a DMH\n            <jats:sup>LepR</jats:sup>\n            neuron subpopulation that projects to the SCN with the capacity to influence the phase of the circadian clock. This direct DMH\n            <jats:sup>LepR</jats:sup>\n            -SCN connection is well situated to integrate the metabolic and circadian systems, facilitating mealtime anticipation.\n          </jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37624889","pmcid":"PMC10456850","openalex_id":null,"authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM121937","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL153916","title":null},{"funder_name":"NEI NIH HHS","grant_id":"R21 EY033528","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R35 GM140854","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM007055","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM007267","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R35GM140854-03","title":"Interplay between circadian and reward pathways in homeostatic response and pathology"},{"funder_name":"National Institutes of Health","grant_id":"5T32GM007055-22","title":"TRAINING IN THE PHARMACOLOGICAL SCIENCES"},{"funder_name":"National Institutes of Health","grant_id":"5R01HL153916-03","title":"Molecular and Functional Taxonomy of Cardiovagal Neurons"},{"funder_name":"National Institutes of Health","grant_id":"5T32GM007267-44","title":"Medical Scientist Training Program"},{"funder_name":"National Institutes of Health","grant_id":"3R01GM121937-03S1","title":"Regulation of central circadian rhythms by dopamine"}],"total_grants":11,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/sciadv.adh9570?download=true","host_type":"publisher"},{"url":"https://www.science.org/doi/pdf/10.1126/sciadv.adh9570","host_type":"publisher"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10456850/pdf/sciadv.adh9570.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10456850","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10456850?pdf=render","host_type":"Europe_PMC"},{"url":"https://doi.org/10.1126/sciadv.adh9570","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/37624889","host_type":""},{"url":"http://dx.doi.org/10.1126/sciadv.adh9570","host_type":""}],"fields_of_study":[],"mesh_terms":["Hypothalamus","Suprachiasmatic Nucleus","Acclimatization","Receptors, Leptin","Circadian Clocks"],"keywords":["Acclimatization","Circadian Clocks","Hypothalamus","Receptors, Leptin","Suprachiasmatic Nucleus","Neuroscience"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"rrid"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T08:17:36.950998Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}