{"doi":"10.1126/sciadv.adh9239","title":"Astrocyte activities in the external globus pallidus regulate action-selection strategies in reward-seeking behaviors","abstract":"An imbalance in goal-directed and habitual behavioral control is a hallmark of decision-making-related disorders, including addiction. Although external globus pallidus (GPe) is critical for action selection, which harbors enriched astrocytes, the role of GPe astrocytes involved in action-selection strategies remained unknown. Using in vivo calcium signaling with fiber photometry, we found substantially attenuated GPe astrocytic activity during habitual learning compared to goal-directed learning. The support vector machine analysis predicted the behavioral outcomes. Chemogenetic activation of the astrocytes or inhibition of GPe pan-neuronal activities facilitates the transition from habit to goal-directed reward-seeking behavior. Next, we found increased astrocyte-specific GABA (γ-aminobutyric acid) transporter type 3 (GAT3) messenger RNA expression during habit learning. Notably, the pharmacological inhibition of GAT3 occluded astrocyte activation-induced transition from habitual to goal-directed behavior. On the other hand, attentional stimuli shifted the habit to goal-directed behaviors. Our findings suggest that the GPe astrocytes regulate the action selection strategy and behavioral flexibility.","journal":"Science Advances","year":2023,"id":328648,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":307614,"name":"Sa‐Ik Hong","orcid":"0000-0003-4799-739X","position":1,"is_corresponding":false},{"id":307613,"name":"Seungwoo Kang","orcid":"0000-0003-1301-8480","position":2,"is_corresponding":false},{"id":1050558,"name":"Minryung Song","orcid":"0000-0002-9292-5988","position":3,"is_corresponding":false},{"id":1050559,"name":"Minsu Abel Yang","orcid":"0000-0001-7685-1280","position":4,"is_corresponding":false},{"id":1050560,"name":"Hesham Essa","orcid":"0000-0001-7974-0105","position":5,"is_corresponding":false},{"id":307617,"name":"Matthew Baker","orcid":"0000-0002-5901-5958","position":6,"is_corresponding":false},{"id":307615,"name":"Jeyeon Lee","orcid":"0000-0002-6168-8385","position":7,"is_corresponding":false},{"id":709521,"name":"Robert A. Bruce","orcid":null,"position":8,"is_corresponding":false},{"id":653932,"name":"Sang Wan Lee","orcid":"0000-0001-6266-9613","position":9,"is_corresponding":false},{"id":307620,"name":"Doo‐Sup Choi","orcid":"0000-0002-6796-9938","position":10,"is_corresponding":false},{"id":715362,"name":"Shinwoo Kang","orcid":"0000-0001-7963-1996","position":0,"is_corresponding":true}],"reference_count":77,"raw_metadata":null,"created_at":"2026-07-19T01:08:56.940647Z","pmid":"37327345","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}