{"doi":"10.1126/sciadv.adh9170","title":"HIV-1 Vpr induces ciTRAN to prevent transcriptional repression of the provirus","abstract":"The functional consequences of circular RNA (circRNA) expression on HIV-1 replication are largely unknown. Using a customized protocol involving direct RNA nanopore sequencing, here, we captured circRNAs from HIV-1-infected T cells and identified ciTRAN, a circRNA that modulates HIV-1 transcription. We found that HIV-1 infection induces ciTRAN expression in a Vpr-dependent manner and that ciTRAN interacts with SRSF1, a protein known to repress HIV-1 transcription. Our results suggest that HIV-1 hijacks ciTRAN to exclude serine/arginine-rich splicing factor 1 (SRSF1) from the viral transcriptional complex, thereby promoting efficient viral transcription. In addition, we demonstrate that an SRSF1-inspired mimic can inhibit viral transcription regardless of ciTRAN induction. The hijacking of a host circRNA thus represents a previously unknown facet of primate lentiviruses in overcoming transmission bottlenecks.","journal":"Science Advances","year":2023,"id":333451,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9611,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":579699,"name":"Aman Singh","orcid":"0000-0001-8946-4247","position":1,"is_corresponding":false},{"id":1061220,"name":"Aditi Choudhary","orcid":null,"position":2,"is_corresponding":false},{"id":811683,"name":"Rishikesh Dalavi","orcid":"0000-0001-6897-4424","position":3,"is_corresponding":false},{"id":989932,"name":"Lalchhanhima Ralte","orcid":null,"position":4,"is_corresponding":false},{"id":989933,"name":"Richard L. Chawngthu","orcid":null,"position":5,"is_corresponding":false},{"id":78367,"name":"Nachimuthu Senthil Kumar","orcid":"0000-0002-0192-2133","position":6,"is_corresponding":false},{"id":579700,"name":"Nagarjun Vijay","orcid":"0000-0002-8703-6991","position":7,"is_corresponding":false},{"id":316635,"name":"Ajit Chande","orcid":"0000-0003-2210-5180","position":8,"is_corresponding":false},{"id":316633,"name":"Vipin Bhardwaj","orcid":"0000-0003-2076-6794","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":null,"created_at":"2026-07-19T01:09:39.719497Z","pmid":"37672576","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}