{"doi":"10.1126/sciadv.adg8558","title":"Transcriptional signatures of heroin intake and relapse throughout the brain reward circuitry in male mice","abstract":"Opioid use disorder (OUD) looms as one of the most severe medical crises facing society. More effective therapeutics will require a deeper understanding of molecular changes supporting drug-taking and relapse. Here, we develop a brain reward circuit-wide atlas of opioid-induced transcriptional regulation by combining RNA sequencing (RNA-seq) and heroin self-administration in male mice modeling multiple OUD-relevant conditions: acute heroin exposure, chronic heroin intake, context-induced drug-seeking following abstinence, and relapse. Bioinformatics analysis of this rich dataset identified numerous patterns of transcriptional regulation, with both region-specific and pan-circuit biological domains affected by heroin. Integration of RNA-seq data with OUD-relevant behavioral outcomes uncovered region-specific molecular changes and biological processes that predispose to OUD vulnerability. Comparisons with human OUD RNA-seq and genome-wide association study data revealed convergent molecular abnormalities and gene candidates with high therapeutic potential. These studies outline molecular reprogramming underlying OUD and provide a foundational resource for future investigations into mechanisms and treatment strategies.","journal":"Science Advances","year":2023,"id":321025,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":46,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8204,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":931818,"name":"Rita Futamura","orcid":"0000-0001-5615-228X","position":1,"is_corresponding":false},{"id":931819,"name":"Angélica Minier-Toribio","orcid":"0000-0002-8860-5973","position":2,"is_corresponding":false},{"id":840208,"name":"Emily M. Hicks","orcid":"0000-0001-9102-9244","position":3,"is_corresponding":false},{"id":328291,"name":"Aarthi Ramakrishnan","orcid":"0000-0002-6329-6502","position":4,"is_corresponding":false},{"id":409557,"name":"Freddyson J. Martínez-Rivera","orcid":"0000-0001-6062-2205","position":5,"is_corresponding":false},{"id":653039,"name":"Molly Estill","orcid":"0009-0007-6322-6989","position":6,"is_corresponding":false},{"id":377067,"name":"Arthur Godino","orcid":"0000-0002-1732-1498","position":7,"is_corresponding":false},{"id":314830,"name":"Eric M. Parise","orcid":"0000-0001-5364-5820","position":8,"is_corresponding":false},{"id":314831,"name":"Angélica Torres‐Berrío","orcid":"0000-0002-4740-0293","position":9,"is_corresponding":false},{"id":702273,"name":"Ashley M. Cunningham","orcid":"0000-0003-2104-0119","position":10,"is_corresponding":false},{"id":566432,"name":"Peter J. Hamilton","orcid":"0000-0002-6819-8346","position":11,"is_corresponding":false},{"id":603271,"name":"Deena M. Walker","orcid":"0000-0002-2085-3751","position":12,"is_corresponding":false},{"id":35431,"name":"Laura M. Huckins","orcid":"0000-0002-5369-6502","position":13,"is_corresponding":false},{"id":284410,"name":"Yasmin L. Hurd","orcid":"0000-0003-0808-2832","position":14,"is_corresponding":false},{"id":328296,"name":"Li Shen","orcid":"0000-0002-5190-2851","position":15,"is_corresponding":false},{"id":196103,"name":"Eric J. Nestler","orcid":"0000-0002-7905-2000","position":16,"is_corresponding":false},{"id":136089,"name":"Caleb J Browne","orcid":"0000-0003-0089-5433","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T01:07:27.434133Z","pmid":"37294757","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}