{"doi":"10.1126/sciadv.adg6075","title":"Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications","abstract":"Amino acid crystals are an attractive piezoelectric material as they have an ultrahigh piezoelectric coefficient and have an appealing safety profile for medical implant applications. Unfortunately, solvent-cast films made from glycine crystals are brittle, quickly dissolve in body fluid, and lack crystal orientation control, reducing the overall piezoelectric effect. Here, we present a material processing strategy to create biodegradable, flexible, and piezoelectric nanofibers of glycine crystals embedded inside polycaprolactone (PCL). The glycine-PCL nanofiber film exhibits stable piezoelectric performance with a high ultrasound output of 334 kPa [under 0.15 voltage root-mean-square (Vrms)], which outperforms the state-of-the-art biodegradable transducers. We use this material to fabricate a biodegradable ultrasound transducer for facilitating the delivery of chemotherapeutic drug to the brain. The device remarkably enhances the animal survival time (twofold) in mice-bearing orthotopic glioblastoma models. The piezoelectric glycine-PCL presented here could offer an excellent platform not only for glioblastoma therapy but also for developing medical implantation fields.","journal":"Science Advances","year":2023,"id":315529,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":153,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9514,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":251536,"name":"Thinh T. Le","orcid":"0000-0002-8180-2077","position":1,"is_corresponding":false},{"id":1014491,"name":"Feng Lin","orcid":"0000-0002-2700-3573","position":2,"is_corresponding":false},{"id":1015503,"name":"Tra Vinikoor","orcid":null,"position":3,"is_corresponding":false},{"id":251534,"name":"Ritopa Das","orcid":"0000-0001-7297-1998","position":4,"is_corresponding":false},{"id":1017571,"name":"James F. Stevens","orcid":null,"position":5,"is_corresponding":false},{"id":1017572,"name":"Caitlyn Mundrane","orcid":null,"position":6,"is_corresponding":false},{"id":1014488,"name":"Jinyoung Park","orcid":"0000-0003-0943-3649","position":7,"is_corresponding":false},{"id":405312,"name":"Khanh T. M. Tran","orcid":"0000-0002-5331-4068","position":8,"is_corresponding":false},{"id":251538,"name":"Yang Liu","orcid":"0000-0003-1655-828X","position":9,"is_corresponding":false},{"id":1017573,"name":"Jacob Pfund","orcid":null,"position":10,"is_corresponding":false},{"id":439400,"name":"Rachel M. Thompson","orcid":"0000-0003-1519-8040","position":11,"is_corresponding":false},{"id":1017574,"name":"He Wu","orcid":null,"position":12,"is_corresponding":false},{"id":1016842,"name":"M. Jain","orcid":"0000-0002-2264-6895","position":13,"is_corresponding":false},{"id":1016843,"name":"M. D. Morales-Acosta","orcid":"0000-0003-1145-9485","position":14,"is_corresponding":false},{"id":1016844,"name":"Osama R. Bilal","orcid":"0000-0003-3803-5084","position":15,"is_corresponding":false},{"id":1016845,"name":"Kazem Kazerounian","orcid":"0009-0004-7115-0070","position":16,"is_corresponding":false},{"id":1016846,"name":"Horea Ilieş","orcid":"0009-0000-1038-4536","position":17,"is_corresponding":false},{"id":251542,"name":"Thanh D. Nguyen","orcid":"0000-0003-0813-4807","position":18,"is_corresponding":false},{"id":1014483,"name":"Meysam T. Chorsi","orcid":"0000-0002-2633-9200","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":null,"created_at":"2026-07-19T01:06:25.560098Z","pmid":"37315129","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}