{"doi":"10.1126/sciadv.adf9016","title":"Mitigation of influenza-mediated inflammation by immunomodulatory matrix-bound nanovesicles","abstract":"Cytokine storm describes a life-threatening, systemic inflammatory syndrome characterized by elevated levels of proinflammatory cytokines and immune cell hyperactivation associated with multi-organ dysfunction. Matrix-bound nanovesicles (MBV) are a subclass of extracellular vesicle shown to down-regulate proinflammatory immune responses. The objective of this study was to assess the efficacy of MBV in mediating influenza-induced acute respiratory distress syndrome and cytokine storm in a murine model. Intravenous administration of MBV decreased influenza-mediated total lung inflammatory cell density, proinflammatory macrophage frequencies, and proinflammatory cytokines at 7 and 21 days following viral inoculation. MBV decreased long-lasting alveolitis and the proportion of lung undergoing inflammatory tissue repair at day 21. MBV increased the proportion of activated anti-viral CD4 + and CD8 + T cells at day 7 and memory-like CD62L + CD44 + , CD4 + , and CD8 + T cells at day 21. These results show immunomodulatory properties of MBV that may benefit the treatment of viral-mediated pulmonary inflammation with applicability to other viral diseases such as SARS-CoV-2.","journal":"Science Advances","year":2023,"id":333291,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9597,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1061111,"name":"Brydie R. Huckestien","orcid":null,"position":1,"is_corresponding":false},{"id":311632,"name":"Gaelen K. Dwyer","orcid":"0000-0001-7491-1171","position":2,"is_corresponding":false},{"id":313063,"name":"Lisa Mathews","orcid":null,"position":3,"is_corresponding":false},{"id":975538,"name":"David Nascari","orcid":"0000-0003-3486-5929","position":4,"is_corresponding":false},{"id":277275,"name":"George S. Hussey","orcid":"0000-0001-5636-0994","position":5,"is_corresponding":false},{"id":311638,"name":"Hēth Turnquist","orcid":"0000-0002-4173-4014","position":6,"is_corresponding":false},{"id":295193,"name":"John F. Alcorn","orcid":"0000-0001-5997-7711","position":7,"is_corresponding":false},{"id":277279,"name":"Stephen F. Badylak","orcid":"0000-0003-3555-0689","position":8,"is_corresponding":false},{"id":352656,"name":"Raphael J. Crum","orcid":"0000-0001-8597-1874","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-19T01:09:39.719497Z","pmid":"37205761","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}