{"doi":"10.1126/sciadv.adf5499","title":"Home-site advantage for host species–specific gut microbiota","abstract":"Mammalian species harbor compositionally distinct gut microbial communities, but the mechanisms that maintain specificity of symbionts to host species remain unclear. Here, we show that natural selection within house mice ( Mus musculus domesticus ) drives deterministic assembly of the house-mouse gut microbiota from mixtures of native and non-native microbiotas. Competing microbiotas from wild-derived lines of house mice and other mouse species ( Mus and Peromyscus spp.) within germ-free wild-type (WT) and Rag1 -knockout ( Rag1 −/− ) house mice revealed widespread fitness advantages for native gut bacteria. Native bacterial lineages significantly outcompeted non-native lineages in both WT and Rag1 −/− mice, indicating home-site advantage for native microbiota independent of host adaptive immunity. However, a minority of native Bacteriodetes and Firmicutes favored by selection in WT hosts were not favored or disfavored in Rag1 −/− hosts, indicating that Rag1 mediates fitness advantages of these strains. This study demonstrates home-site advantage for native gut bacteria, consistent with local adaptation of gut microbiota to their mammalian species.","journal":"Science Advances","year":2023,"id":321656,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9501,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":993763,"name":"Jeffrey D. Price","orcid":null,"position":1,"is_corresponding":false},{"id":993183,"name":"Anthony F. Juritsch","orcid":"0000-0001-6277-283X","position":2,"is_corresponding":false},{"id":993764,"name":"Robert Schmaltz","orcid":null,"position":3,"is_corresponding":false},{"id":993184,"name":"Madalena V. F. Real","orcid":"0000-0003-0550-8252","position":4,"is_corresponding":false},{"id":745884,"name":"Samantha L. Goldman","orcid":"0000-0001-9577-6626","position":5,"is_corresponding":false},{"id":363354,"name":"Michael J. Sheehan","orcid":"0000-0002-3949-7873","position":6,"is_corresponding":false},{"id":108892,"name":"Amanda E. Ramer‐Tait","orcid":"0000-0003-0950-7548","position":7,"is_corresponding":false},{"id":263191,"name":"Andrew H. Moeller","orcid":"0000-0002-8377-4647","position":8,"is_corresponding":false},{"id":356871,"name":"Daniel D. Sprockett","orcid":"0000-0003-2620-7555","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T01:07:37.596550Z","pmid":"37184968","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}