{"doi":"10.1126/sciadv.adf2898","title":"Nanowired human cardiac organoid transplantation enables highly efficient and effective recovery of infarcted hearts","abstract":"Human cardiac organoids hold remarkable potential for cardiovascular disease modeling and human pluripotent stem cell-derived cardiomyocyte (hPSC-CM) transplantation. Here, we show cardiac organoids engineered with electrically conductive silicon nanowires (e-SiNWs) significantly enhance the therapeutic efficacy of hPSC-CMs to treat infarcted hearts. We first demonstrated the biocompatibility of e-SiNWs and their capacity to improve cardiac microtissue engraftment in healthy rat myocardium. Nanowired human cardiac organoids were then engineered with hPSC-CMs, nonmyocyte supporting cells, and e-SiNWs. Nonmyocyte supporting cells promoted greater ischemia tolerance of cardiac organoids, and e-SiNWs significantly improved electrical pacing capacity. After transplantation into ischemia/reperfusion-injured rat hearts, nanowired cardiac organoids significantly improved contractile development of engrafted hPSC-CMs, induced potent cardiac functional recovery, and reduced maladaptive left ventricular remodeling. Compared to contemporary studies with an identical injury model, greater functional recovery was achieved with a 20-fold lower dose of hPSC-CMs, revealing therapeutic synergy between conductive nanomaterials and human cardiac organoids for efficient heart repair.","journal":"Science Advances","year":2023,"id":319513,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":55,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9488,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":229867,"name":"Robert C. Coyle","orcid":null,"position":1,"is_corresponding":false},{"id":494229,"name":"Ryan W. Barrs","orcid":"0000-0001-7747-1941","position":2,"is_corresponding":false},{"id":666720,"name":"Sophia E. Silver","orcid":"0000-0003-0718-591X","position":3,"is_corresponding":false},{"id":1028438,"name":"Mei Li","orcid":"0000-0002-4264-8505","position":4,"is_corresponding":false},{"id":228499,"name":"Dylan Richards","orcid":"0000-0002-5823-0859","position":5,"is_corresponding":false},{"id":483103,"name":"Yiliang Lin","orcid":"0000-0001-9403-9464","position":6,"is_corresponding":false},{"id":988438,"name":"Yuanwen Jiang","orcid":"0000-0002-2056-2639","position":7,"is_corresponding":false},{"id":486699,"name":"Hongjun Wang","orcid":"0000-0001-7421-1917","position":8,"is_corresponding":false},{"id":229869,"name":"Donald R. Menick","orcid":null,"position":9,"is_corresponding":false},{"id":40576,"name":"Kristine Y. DeLeon-Pennell","orcid":"0000-0002-9647-6112","position":10,"is_corresponding":false},{"id":274975,"name":"Bozhi Tian","orcid":"0000-0003-0593-0023","position":11,"is_corresponding":false},{"id":228510,"name":"Ying Mei","orcid":"0000-0002-8508-4076","position":12,"is_corresponding":false},{"id":1028437,"name":"Yu Tan","orcid":"0000-0002-0608-9179","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T01:07:12.004111Z","pmid":"37540743","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}