{"doi":"10.1126/sciadv.ade5492","title":"H/ACA snRNP–dependent ribosome biogenesis regulates translation of polyglutamine proteins","abstract":"germline stem cells (GSCs), increase ribosome biogenesis and translation during terminal differentiation. Here, we show that the H/ACA small nuclear ribonucleoprotein (snRNP) complex that promotes pseudouridylation of ribosomal RNA (rRNA) and ribosome biogenesis is required for oocyte specification. Reducing ribosome levels during differentiation decreased the translation of a subset of messenger RNAs that are enriched for CAG trinucleotide repeats and encode polyglutamine-containing proteins, including differentiation factors such as RNA-binding Fox protein 1. Moreover, ribosomes were enriched at CAG repeats within transcripts during oogenesis. Increasing target of rapamycin (TOR) activity to elevate ribosome levels in H/ACA snRNP complex-depleted germlines suppressed the GSC differentiation defects, whereas germlines treated with the TOR inhibitor rapamycin had reduced levels of polyglutamine-containing proteins. Thus, ribosome biogenesis and ribosome levels can control stem cell differentiation via selective translation of CAG repeat-containing transcripts.","journal":"Science Advances","year":2023,"id":357886,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9557,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":960413,"name":"Yingshi Peng","orcid":"0000-0002-4291-8069","position":1,"is_corresponding":false},{"id":992990,"name":"Limin Deng","orcid":null,"position":2,"is_corresponding":false},{"id":449458,"name":"Noor M. Kotb","orcid":"0009-0008-5301-2749","position":3,"is_corresponding":false},{"id":74686,"name":"Zachary Flamholz","orcid":"0000-0002-0129-8836","position":4,"is_corresponding":false},{"id":992642,"name":"Ian T. Rapisarda","orcid":"0000-0002-6271-360X","position":5,"is_corresponding":false},{"id":696949,"name":"Elliot T. Martin","orcid":"0000-0002-1832-0665","position":6,"is_corresponding":false},{"id":992991,"name":"Kara A. LaBarge","orcid":null,"position":7,"is_corresponding":false},{"id":625820,"name":"Daniele Fabris","orcid":"0000-0003-0786-1578","position":8,"is_corresponding":false},{"id":279106,"name":"Elizabeth R. Gavis","orcid":"0000-0003-0251-0760","position":9,"is_corresponding":false},{"id":567403,"name":"Prashanth Rangan","orcid":"0000-0002-1452-8119","position":10,"is_corresponding":false},{"id":567400,"name":"Shane Breznak","orcid":"0000-0003-0229-5060","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T01:13:39.186262Z","pmid":"37343092","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}