{"doi":"10.1126/sciadv.add8687","title":"Role of ventral subiculum neuronal ensembles in incubation of oxycodone craving after electric barrier–induced voluntary abstinence","abstract":"High relapse rate is a key feature of opioid addiction. In humans, abstinence is often voluntary due to negative consequences of opioid seeking. To mimic this human condition, we recently introduced a rat model of incubation of oxycodone craving after electric barrier-induced voluntary abstinence. Incubation of drug craving refers to time-dependent increases in drug seeking after cessation of drug self-administration. Here, we used the activity marker Fos, muscimol-baclofen (GABAa + GABAb receptor agonists) global inactivation, Daun02-selective inactivation of putative relapse-associated neuronal ensembles, and fluorescence-activated cell sorting of Fos-positive cells and quantitative polymerase chain reaction to demonstrate a key role of vSub neuronal ensembles in incubation of oxycodone craving after voluntary abstinence, but not homecage forced abstinence. We also used a longitudinal functional magnetic resonance imaging method and showed that functional connectivity changes in vSub-related circuits predict opioid relapse after abstinence induced by adverse consequences of opioid seeking.","journal":"Science Advances","year":2023,"id":324519,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9496,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":291963,"name":"Pei-Jung Tsai","orcid":"0000-0002-1149-0311","position":1,"is_corresponding":false},{"id":670623,"name":"Aniruddha Shekara","orcid":"0000-0003-2392-6079","position":2,"is_corresponding":false},{"id":670624,"name":"Ying Duan","orcid":"0000-0002-2551-9293","position":3,"is_corresponding":false},{"id":670625,"name":"Sarah V. Applebey","orcid":"0000-0002-8162-8785","position":4,"is_corresponding":false},{"id":931819,"name":"Angélica Minier-Toribio","orcid":"0000-0002-8860-5973","position":5,"is_corresponding":false},{"id":1041210,"name":"Ashley Batista","orcid":null,"position":6,"is_corresponding":false},{"id":447538,"name":"Jonathan J. Chow","orcid":"0000-0001-5999-145X","position":7,"is_corresponding":false},{"id":694963,"name":"Lindsay Altidor","orcid":"0000-0003-4475-4077","position":8,"is_corresponding":false},{"id":636624,"name":"Estelle Barbier","orcid":"0000-0001-6924-1855","position":9,"is_corresponding":false},{"id":515079,"name":"Carlo Cifani","orcid":"0000-0001-6180-828X","position":10,"is_corresponding":false},{"id":1040691,"name":"Xuan Li","orcid":"0000-0002-6737-1223","position":11,"is_corresponding":false},{"id":636506,"name":"David J. Reiner","orcid":"0000-0002-5799-366X","position":12,"is_corresponding":false},{"id":355726,"name":"F. Javier Rubio","orcid":"0000-0001-5480-0474","position":13,"is_corresponding":false},{"id":355729,"name":"Bruce T. Hope","orcid":"0000-0001-5804-7061","position":14,"is_corresponding":false},{"id":291970,"name":"Yihong Yang","orcid":"0000-0002-1035-5038","position":15,"is_corresponding":false},{"id":355727,"name":"Jennifer M. Bossert","orcid":"0000-0001-5636-4071","position":16,"is_corresponding":false},{"id":288988,"name":"Yavin Shaham","orcid":"0000-0002-8242-3319","position":17,"is_corresponding":false},{"id":356297,"name":"Ida Fredriksson","orcid":"0000-0002-3443-3870","position":0,"is_corresponding":true}],"reference_count":80,"raw_metadata":null,"created_at":"2026-07-19T01:08:11.275604Z","pmid":"36630511","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}