{"doi":"10.1126/sciadv.add5501","title":"Genetics of mirror movements identifies a multifunctional complex required for Netrin-1 guidance and lateralization of motor control","abstract":"Mirror movements (MM) disorder is characterized by involuntary movements on one side of the body that mirror intentional movements on the opposite side. We performed genetic characterization of a family with autosomal dominant MM and identified ARHGEF7 , a RhoGEF, as a candidate MM gene. We found that Arhgef7 and its partner Git1 bind directly to Dcc. Dcc is the receptor for Netrin-1, an axon guidance cue that attracts commissural axons to the midline, promoting the midline crossing of axon tracts. We show that Arhgef7 and Git1 are required for Netrin-1–mediated axon guidance and act as a multifunctional effector complex. Arhgef7/Git1 activates Rac1 and Cdc42 and inhibits Arf1 downstream of Netrin-1. Furthermore, Arhgef7/Git1, via Arf1, mediates the Netrin-1–induced increase in cell surface Dcc. Mice heterozygous for Arhgef7 have defects in commissural axon trajectories and increased symmetrical paw placements during skilled walking, a MM-like phenotype. Thus, we have delineated how ARHGEF7 mutation causes MM.","journal":"Science Advances","year":2023,"id":334582,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.95,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":589708,"name":"Patricia T. Yam","orcid":"0000-0002-3631-3151","position":1,"is_corresponding":false},{"id":1064046,"name":"Nursen Balekoglu","orcid":null,"position":2,"is_corresponding":false},{"id":1063356,"name":"Hugo Ducuing","orcid":"0000-0001-8227-7924","position":3,"is_corresponding":false},{"id":1063357,"name":"J. Michaud","orcid":"0000-0002-2155-7209","position":4,"is_corresponding":false},{"id":1063358,"name":"Shirin Makihara","orcid":"0000-0001-6787-4851","position":5,"is_corresponding":false},{"id":709098,"name":"Daniel A. Kramer","orcid":"0000-0002-7159-9562","position":6,"is_corresponding":false},{"id":281969,"name":"Baoyu Chen","orcid":"0000-0002-6366-159X","position":7,"is_corresponding":false},{"id":263851,"name":"Alfonso Fasano","orcid":"0000-0001-5346-0180","position":8,"is_corresponding":false},{"id":347471,"name":"Alfredo Berardelli","orcid":"0000-0003-3598-3142","position":9,"is_corresponding":false},{"id":669686,"name":"Fadi F. Hamdan","orcid":"0000-0002-0266-2476","position":10,"is_corresponding":false},{"id":53271,"name":"Guy A. Rouleau","orcid":"0000-0001-8403-1418","position":11,"is_corresponding":false},{"id":669678,"name":"Myriam Srour","orcid":"0000-0003-1009-0508","position":12,"is_corresponding":false},{"id":589707,"name":"Frédéric Charron","orcid":"0000-0003-3483-8672","position":13,"is_corresponding":false},{"id":989437,"name":"Sabrina Schlienger","orcid":"0000-0002-1111-0737","position":0,"is_corresponding":true}],"reference_count":80,"raw_metadata":null,"created_at":"2026-07-19T01:09:53.742667Z","pmid":"37172092","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}