{"doi":"10.1126/sciadv.abq7595","title":"Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell–mediated limbic encephalitis","abstract":"Autoimmune limbic encephalitis (ALE) presents with new-onset mesial temporal lobe seizures, progressive memory disturbance, and other behavioral and cognitive changes. CD8 T cells are considered to play a key role in those cases where autoantibodies (ABs) target intracellular antigens or no ABs were found. Assessment of such patients presents a clinical challenge, and novel noninvasive imaging biomarkers are urgently needed. Here, we demonstrate that visualization of the translocator protein (TSPO) with [ 18 F]DPA-714-PET-MRI reveals pronounced microglia activation and reactive gliosis in the hippocampus and amygdala of patients suspected with CD8 T cell ALE, which correlates with FLAIR-MRI and EEG alterations. Back-translation into a preclinical mouse model of neuronal antigen-specific CD8 T cell–mediated ALE allowed us to corroborate our preliminary clinical findings. These translational data underline the potential of [ 18 F]DPA-714-PET-MRI as a clinical molecular imaging method for the direct assessment of innate immunity in CD8 T cell–mediated ALE.","journal":"Science Advances","year":2023,"id":325797,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1044108,"name":"Wolfgang Roll","orcid":"0000-0002-3746-9393","position":1,"is_corresponding":false},{"id":1044109,"name":"Andre Dik","orcid":"0000-0003-4695-4136","position":2,"is_corresponding":false},{"id":1044110,"name":"Cristina Barca","orcid":"0000-0001-8034-2948","position":3,"is_corresponding":false},{"id":1044111,"name":"Bastian Zinnhardt","orcid":"0000-0002-8274-9108","position":4,"is_corresponding":false},{"id":1044690,"name":"Gordon Hicking","orcid":null,"position":5,"is_corresponding":false},{"id":348672,"name":"Christoph Mueller","orcid":"0000-0001-9816-1686","position":6,"is_corresponding":false},{"id":1038458,"name":"Venu Narayanan Naik","orcid":"0000-0002-3637-4173","position":7,"is_corresponding":false},{"id":404799,"name":"Max Anstötz","orcid":"0000-0003-3071-5835","position":8,"is_corresponding":false},{"id":622708,"name":"Julia Krämer","orcid":"0000-0003-2219-5593","position":9,"is_corresponding":false},{"id":1044112,"name":"Leoni Rolfes","orcid":"0000-0003-4494-951X","position":10,"is_corresponding":false},{"id":1044113,"name":"Lydia Wachsmuth","orcid":"0000-0003-1684-7196","position":11,"is_corresponding":false},{"id":1044114,"name":"Julika Pitsch","orcid":"0000-0002-6688-4916","position":12,"is_corresponding":false},{"id":1044115,"name":"Karen M. 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