{"doi":"10.1126/sciadv.abq7469","title":"Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation","abstract":"Monitoring and control of cardiac function are critical for investigation of cardiovascular pathophysiology and developing life-saving therapies. However, chronic stimulation of the heart in freely moving small animal subjects, which offer a variety of genotypes and phenotypes, is currently difficult. Specifically, real-time control of cardiac function with high spatial and temporal resolution is currently not possible. Here, we introduce a wireless battery-free device with on-board computation for real-time cardiac control with multisite stimulation enabling optogenetic modulation of the entire rodent heart. Seamless integration of the biointerface with the heart is enabled by machine learning-guided design of ultrathin arrays. Long-term pacing, recording, and on-board computation are demonstrated in freely moving animals. This device class enables new heart failure models and offers a platform to test real-time therapeutic paradigms over chronic time scales by providing means to control cardiac function continuously over the lifetime of the subject.","journal":"Science Advances","year":2022,"id":236254,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":71,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9512,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":761234,"name":"Micah Madrid","orcid":"0000-0002-7527-022X","position":1,"is_corresponding":false},{"id":456561,"name":"Rose T. Yin","orcid":"0000-0001-5887-9212","position":2,"is_corresponding":false},{"id":856129,"name":"Jessica Hanna","orcid":"0000-0002-7284-5956","position":3,"is_corresponding":false},{"id":856130,"name":"Suzanne Arnott","orcid":"0000-0003-4402-236X","position":4,"is_corresponding":false},{"id":319037,"name":"Jaclyn A. Brennan","orcid":null,"position":5,"is_corresponding":false},{"id":572899,"name":"Roberto Peralta","orcid":"0000-0003-3429-7466","position":6,"is_corresponding":false},{"id":856131,"name":"David Clausen","orcid":"0000-0002-3566-1859","position":7,"is_corresponding":false},{"id":650666,"name":"Jakob A. Bakall","orcid":null,"position":8,"is_corresponding":false},{"id":317055,"name":"Igor R. Efimov","orcid":"0000-0002-1483-5039","position":9,"is_corresponding":false},{"id":474782,"name":"Philipp Gutruf","orcid":"0000-0002-7183-7268","position":10,"is_corresponding":false},{"id":572897,"name":"Jokubas Ausra","orcid":"0000-0002-4860-6197","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T00:21:58.728756Z","pmid":"36288311","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}