{"doi":"10.1126/sciadv.abq5095","title":"A “best-in-class” systemic biomarker predictor of clinically relevant knee osteoarthritis structural and pain progression","abstract":"We aimed to identify markers in blood (serum) to predict clinically relevant knee osteoarthritis (OA) progression defined as the combination of both joint structure and pain worsening over 48 months. A set of 15 serum proteomic markers corresponding to 13 total proteins reached an area under the receiver operating characteristic curve (AUC) of 73% for distinguishing progressors from nonprogressors in a cohort of 596 individuals with knee OA. Prediction based on these blood markers was far better than traditional prediction based on baseline structural OA and pain severity (59%) or the current \"best-in-class\" biomarker for predicting OA progression, urinary carboxyl-terminal cross-linked telopeptide of type II collagen (58%). The generalizability of the marker set was confirmed in a second cohort of 86 individuals that yielded an AUC of 70% for distinguishing joint structural progressors. Blood is a readily accessible biospecimen whose analysis for these biomarkers could facilitate identification of individuals for clinical trial enrollment and those most in need of treatment.","journal":"Science Advances","year":2023,"id":321322,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9549,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":286134,"name":"Yi‐Ju Li","orcid":"0000-0001-6996-4834","position":1,"is_corresponding":false},{"id":514967,"name":"Erik J. Soderblom","orcid":"0000-0002-6765-1786","position":2,"is_corresponding":false},{"id":428989,"name":"Alexander Reed","orcid":"0000-0003-3340-0214","position":3,"is_corresponding":false},{"id":229144,"name":"Vaibhav Jain","orcid":"0000-0003-2394-3426","position":4,"is_corresponding":false},{"id":1033365,"name":"Shuming Sun","orcid":"0000-0001-7525-8979","position":5,"is_corresponding":false},{"id":32984,"name":"M. Arthur Moseley","orcid":"0000-0001-9907-738X","position":6,"is_corresponding":false},{"id":33062,"name":"Virginia B. Kraus","orcid":"0000-0001-8173-8258","position":7,"is_corresponding":false},{"id":1033364,"name":"Kaile Zhou","orcid":"0000-0002-1000-8589","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T01:07:32.611759Z","pmid":"36696492","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}