{"doi":"10.1126/sciadv.abn7232","title":"Molecular architecture of the human caveolin-1 complex","abstract":"Membrane-sculpting proteins shape the morphology of cell membranes and facilitate remodeling in response to physiological and environmental cues. Complexes of the monotopic membrane protein caveolin function as essential curvature-generating components of caveolae, flask-shaped invaginations that sense and respond to plasma membrane tension. However, the structural basis for caveolin's membrane remodeling activity is currently unknown. Here, we show that, using cryo-electron microscopy, the human caveolin-1 complex is composed of 11 protomers organized into a tightly packed disc with a flat membrane-embedded surface. The structural insights suggest a previously unrecognized mechanism for how membrane-sculpting proteins interact with membranes and reveal how key regions of caveolin-1, including its scaffolding, oligomerization, and intramembrane domains, contribute to its function.","journal":"Science Advances","year":2022,"id":233547,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":124,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9557,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":467085,"name":"Bing Han","orcid":"0000-0001-6952-7482","position":1,"is_corresponding":false},{"id":426774,"name":"Alican Gulsevin","orcid":"0000-0002-8724-5777","position":2,"is_corresponding":false},{"id":302286,"name":"Jeong Min Chung","orcid":"0000-0002-4285-8764","position":3,"is_corresponding":false},{"id":467088,"name":"Yelena Peskova","orcid":"0000-0002-8220-5733","position":4,"is_corresponding":false},{"id":847619,"name":"Sarah M. Connolly","orcid":"0000-0001-7628-9400","position":5,"is_corresponding":false},{"id":298192,"name":"Hassane S. Mchaourab","orcid":"0000-0002-5673-0980","position":6,"is_corresponding":false},{"id":36757,"name":"Jens Meiler","orcid":"0000-0001-8945-193X","position":7,"is_corresponding":false},{"id":467089,"name":"Erkan Karakaş","orcid":"0000-0001-6552-3185","position":8,"is_corresponding":false},{"id":298135,"name":"Anne K. Kenworthy","orcid":"0000-0001-6567-9059","position":9,"is_corresponding":false},{"id":260326,"name":"Melanie D. Ohi","orcid":"0000-0003-1750-4793","position":10,"is_corresponding":false},{"id":467086,"name":"Jason C. Porta","orcid":"0000-0002-5457-5526","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-19T00:21:31.237180Z","pmid":"35544577","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}