{"doi":"10.1126/sciadv.abn5315","title":"Experimental and computational understanding of pulsatile release mechanism from biodegradable core-shell microparticles","abstract":"Next-generation therapeutics require advanced drug delivery platforms with precise control over morphology and release kinetics. A recently developed microfabrication technique enables fabrication of a new class of injectable microparticles with a hollow core-shell structure that displays pulsatile release kinetics, providing such capabilities. Here, we study this technology and the resulting core-shell microstructures. We demonstrated that pulsatile release is governed by a sudden increase in porosity of the polymeric matrix, leading to the formation of a porous path connecting the core to the environment. Moreover, the release kinetics within the range studied remained primarily independent of the particle geometry but highly dependent on its composition. A qualitative technique was developed to study the pattern of pH evolution in the particles. A computational model successfully modeled deformations, indicating sudden expansion of the particle before onset of release. Results of this study contribute to the understanding and design of advanced drug delivery systems.","journal":"Science Advances","year":2022,"id":246688,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.95,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":883987,"name":"Christina Ta","orcid":null,"position":1,"is_corresponding":false},{"id":883988,"name":"Abigail M. VanLonkhuyzen","orcid":null,"position":2,"is_corresponding":false},{"id":883372,"name":"Dominique C. De Fiesta","orcid":"0000-0003-3579-160X","position":3,"is_corresponding":false},{"id":883373,"name":"Maria Kanelli","orcid":"0000-0002-0031-8866","position":4,"is_corresponding":false},{"id":883374,"name":"Ilin Sadeghi","orcid":"0000-0002-3451-0709","position":5,"is_corresponding":false},{"id":310052,"name":"Adam M. Behrens","orcid":null,"position":6,"is_corresponding":false},{"id":883375,"name":"Bailey Ingalls","orcid":"0000-0002-9586-4631","position":7,"is_corresponding":false},{"id":883376,"name":"Nandita Menon","orcid":"0000-0003-3076-4004","position":8,"is_corresponding":false},{"id":883377,"name":"John L. Daristotle","orcid":"0000-0002-3523-5390","position":9,"is_corresponding":false},{"id":883989,"name":"Julie Yu","orcid":null,"position":10,"is_corresponding":false},{"id":40706,"name":"Robert Langer","orcid":"0000-0003-4255-0492","position":11,"is_corresponding":false},{"id":308815,"name":"Ana Jaklenec","orcid":"0000-0001-6096-0538","position":12,"is_corresponding":false},{"id":308810,"name":"Morteza Sarmadi","orcid":"0000-0001-9018-4066","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T00:23:48.622830Z","pmid":"35857507","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}