{"doi":"10.1126/sciadv.abm9132","title":"Real-time 3D optoacoustic tracking of cell-sized magnetic microrobots circulating in the mouse brain vasculature","abstract":"Mobile microrobots hold remarkable potential to revolutionize health care by enabling unprecedented active medical interventions and theranostics, such as active cargo delivery and microsurgical manipulations in hard-to-reach body sites. High-resolution imaging and control of cell-sized microrobots in the in vivo vascular system remains an unsolved challenge toward their clinical use. To overcome this limitation, we propose noninvasive real-time detection and tracking of circulating microrobots using optoacoustic imaging. We devised cell-sized nickel-based spherical Janus magnetic microrobots whose near-infrared optoacoustic signature is enhanced via gold conjugation. The 5-, 10-, and 20-μm-diameter microrobots are detected volumetrically both in bloodless ex vivo tissues and under real-life conditions with a strongly light-absorbing blood background. We further demonstrate real-time three-dimensional tracking and magnetic manipulation of the microrobots circulating in murine cerebral vasculature, thus paving the way toward effective and safe operation of cell-sized microrobots in challenging and clinically relevant intravascular environments.","journal":"Science Advances","year":2022,"id":233325,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":133,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9472,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":847215,"name":"Oleksiy Degtyaruk","orcid":null,"position":1,"is_corresponding":false},{"id":727558,"name":"Sandeep Kumar Kalva","orcid":"0000-0003-1034-7246","position":2,"is_corresponding":false},{"id":701945,"name":"Xosé Luís Deán‐Ben","orcid":"0000-0002-8557-7778","position":3,"is_corresponding":false},{"id":846228,"name":"Ugur Bozuyuk","orcid":"0000-0001-9555-2307","position":4,"is_corresponding":false},{"id":846229,"name":"Amirreza Aghakhani","orcid":"0000-0002-4301-4053","position":5,"is_corresponding":false},{"id":846230,"name":"Mukrime Birgul Akolpoglu","orcid":"0000-0002-2410-0351","position":6,"is_corresponding":false},{"id":846231,"name":"Metin Sitti","orcid":"0000-0001-8249-3854","position":7,"is_corresponding":false},{"id":499576,"name":"Daniel Razansky","orcid":"0000-0001-8676-0964","position":8,"is_corresponding":false},{"id":846227,"name":"Paul Wrede","orcid":"0000-0002-0702-6428","position":0,"is_corresponding":true}],"reference_count":77,"raw_metadata":null,"created_at":"2026-07-19T00:21:25.223756Z","pmid":"35544570","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}