{"doi":"10.1126/sciadv.abm5164","title":"Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods","abstract":"High-throughput proteomic profiling using antibody or aptamer-based affinity reagents is used increasingly in human studies. However, direct analyses to address the relative strengths and weaknesses of these platforms are lacking. We assessed findings from the SomaScan1.3K ( N = 1301 reagents), the SomaScan5K platform ( N = 4979 reagents), and the Olink Explore ( N = 1472 reagents) profiling techniques in 568 adults from the Jackson Heart Study and 219 participants in the HERITAGE Family Study across four performance domains: precision, accuracy, analytic breadth, and phenotypic associations leveraging detailed clinical phenotyping and genetic data. Across these studies, we show evidence supporting more reliable protein target specificity and a higher number of phenotypic associations for the Olink platform, while the Soma platforms benefit from greater measurement precision and analytic breadth across the proteome.","journal":"Science Advances","year":2022,"id":232362,"datarank":5.745377852903347,"base_score":5.365976015021851,"endowment":5.365976015021851,"self_citation_contribution":0.8048964022532777,"citation_network_contribution":4.9404814506500685,"self_endowment_contribution":0.8048964022532777,"citer_contribution":4.9404814506500685,"corpus_percentile":null,"corpus_rank":null,"citation_count":213,"citer_count":191,"citers_with_citation_signal":150,"citers_with_endowment":150,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.946,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":553494,"name":"Jeremy Robbins","orcid":"0000-0002-9672-4841","position":1,"is_corresponding":false},{"id":360773,"name":"Shuliang Deng","orcid":"0000-0002-1543-2733","position":2,"is_corresponding":false},{"id":461732,"name":"Usman A. Tahir","orcid":"0000-0002-3657-6082","position":3,"is_corresponding":false},{"id":27378,"name":"Alexander G. Bick","orcid":"0000-0001-5824-9595","position":4,"is_corresponding":false},{"id":51210,"name":"Akhil Pampana","orcid":"0000-0002-4167-0540","position":5,"is_corresponding":false},{"id":639171,"name":"Zhi Yu","orcid":"0000-0003-4810-3474","position":6,"is_corresponding":false},{"id":268745,"name":"Debby Ngo","orcid":"0000-0003-2681-3475","position":7,"is_corresponding":false},{"id":553490,"name":"Mark D. Benson","orcid":"0000-0001-8977-2389","position":8,"is_corresponding":false},{"id":553495,"name":"Zsu‐Zsu Chen","orcid":"0000-0001-9441-675X","position":9,"is_corresponding":false},{"id":553496,"name":"Daniel E. Cruz","orcid":"0000-0002-2576-7051","position":10,"is_corresponding":false},{"id":553493,"name":"Dongxiao Shen","orcid":"0000-0003-4164-0402","position":11,"is_corresponding":false},{"id":553491,"name":"Yan Gao","orcid":"0000-0002-2901-6933","position":12,"is_corresponding":false},{"id":400099,"name":"Claude Bouchard","orcid":"0000-0002-0048-491X","position":13,"is_corresponding":false},{"id":21934,"name":"Mark A. Sarzynski","orcid":"0000-0001-6705-0668","position":14,"is_corresponding":false},{"id":1046,"name":"Adolfo Correa","orcid":"0000-0002-9501-600X","position":15,"is_corresponding":false},{"id":24665,"name":"Pradeep Natarajan","orcid":"0000-0001-8402-7435","position":16,"is_corresponding":false},{"id":1133,"name":"James G. Wilson","orcid":"0009-0002-0283-2970","position":17,"is_corresponding":false},{"id":268751,"name":"Robert E. Gerszten","orcid":"0000-0002-6767-7687","position":18,"is_corresponding":false},{"id":536804,"name":"Daniel H. Katz","orcid":"0000-0001-7237-8502","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:21:12.348693Z","pmid":"35984888","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}