{"doi":"10.1126/sciadv.abl8861","title":"Release of CHK-2 from PPM-1.D anchorage schedules meiotic entry","abstract":"Transition from the stem/progenitor cell fate to meiosis is mediated by several redundant posttranscriptional regulatory pathways in Caenorhabditis elegans . Interfering with all three branches causes tumorous germ lines. SCF PROM-1 comprises one branch and mediates a scheduled degradation step at entry into meiosis. prom-1 mutants show defects in the timely initiation of meiotic prophase I events, resulting in high rates of embryonic lethality. Here, we identify the phosphatase PPM-1.D/Wip1 as crucial substrate for PROM-1. We report that PPM-1.D antagonizes CHK-2 kinase, a key regulator for meiotic prophase initiation, including DNA double-strand breaks, chromosome pairing, and synaptonemal complex formation. We propose that PPM-1.D controls the amount of active CHK-2 via both catalytic and noncatalytic activities; notably, noncatalytic regulation seems to be crucial at meiotic entry. PPM-1.D sequesters CHK-2 at the nuclear periphery, and programmed SCF PROM-1 –mediated degradation of PPM-1.D liberates the kinase and promotes meiotic entry.","journal":"Science Advances","year":2022,"id":258390,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.944,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":470298,"name":"Dimitra Paouneskou","orcid":"0009-0007-5942-1829","position":1,"is_corresponding":false},{"id":348754,"name":"Ariz Mohammad","orcid":"0000-0002-2807-412X","position":2,"is_corresponding":false},{"id":813708,"name":"Raffael Lichtenberger","orcid":null,"position":3,"is_corresponding":false},{"id":813029,"name":"Joshua Blundon","orcid":"0009-0009-8412-6818","position":4,"is_corresponding":false},{"id":302749,"name":"Yumi Kim","orcid":"0000-0002-6110-5936","position":5,"is_corresponding":false},{"id":114373,"name":"Markus Hartl","orcid":"0000-0002-4970-7336","position":6,"is_corresponding":false},{"id":813030,"name":"Sebastian Falk","orcid":"0000-0001-7848-4621","position":7,"is_corresponding":false},{"id":246656,"name":"Tim Schedl","orcid":"0000-0003-2148-2996","position":8,"is_corresponding":false},{"id":468237,"name":"Verena Jantsch","orcid":"0000-0002-1978-682X","position":9,"is_corresponding":false},{"id":468235,"name":"Antoine Baudrimont","orcid":"0000-0001-9410-6356","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T00:25:38.634785Z","pmid":"35171669","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}