{"doi":"10.1126/sciadv.abj8750","title":"A developmental reduction of the excitation:inhibition ratio in association cortex during adolescence","abstract":"Adolescence is hypothesized to be a critical period for the development of association cortex. A reduction of the excitation:inhibition (E:I) ratio is a hallmark of critical period development; however, it has been unclear how to assess the development of the E:I ratio using noninvasive neuroimaging techniques. Here, we used pharmacological fMRI with a GABAergic benzodiazepine challenge to empirically generate a model of E:I ratio based on multivariate patterns of functional connectivity. In an independent sample of 879 youth (ages 8 to 22 years), this model predicted reductions in the E:I ratio during adolescence, which were specific to association cortex and related to psychopathology. These findings support hypothesized shifts in E:I balance of association cortices during a neurodevelopmental critical period in adolescence.","journal":"Science Advances","year":2022,"id":235287,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":82,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9627,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":235284,"name":"Zaixu Cui","orcid":"0000-0003-4385-8106","position":1,"is_corresponding":false},{"id":235287,"name":"Azeez Adebimpe","orcid":"0000-0001-9049-0135","position":2,"is_corresponding":false},{"id":285908,"name":"Adam Pines","orcid":"0000-0001-9740-3196","position":3,"is_corresponding":false},{"id":52339,"name":"Aaron Alexander-Bloch","orcid":"0000-0001-6554-1893","position":4,"is_corresponding":false},{"id":754153,"name":"Max Bertolero","orcid":null,"position":5,"is_corresponding":false},{"id":263910,"name":"Monica E. Calkins","orcid":"0000-0002-0546-0263","position":6,"is_corresponding":false},{"id":230042,"name":"Raquel E. Gur","orcid":"0000-0002-4082-8502","position":7,"is_corresponding":false},{"id":230043,"name":"Ruben C. Gur","orcid":"0000-0002-9657-1996","position":8,"is_corresponding":false},{"id":814239,"name":"Arun S. Mahadevan","orcid":"0000-0001-7315-8261","position":9,"is_corresponding":false},{"id":235289,"name":"Tyler M. Moore","orcid":"0000-0002-1384-0151","position":10,"is_corresponding":false},{"id":235291,"name":"David R. Roalf","orcid":"0000-0002-1728-9782","position":11,"is_corresponding":false},{"id":52331,"name":"Jakob Seidlitz","orcid":"0000-0002-8164-7476","position":12,"is_corresponding":false},{"id":274928,"name":"Valerie J. Sydnor","orcid":"0000-0002-8640-668X","position":13,"is_corresponding":false},{"id":230041,"name":"Daniel H. Wolf","orcid":"0000-0002-9731-8781","position":14,"is_corresponding":false},{"id":230040,"name":"Theodore D. Satterthwaite","orcid":"0000-0001-7072-9399","position":15,"is_corresponding":false},{"id":274058,"name":"Bart Larsen","orcid":"0000-0001-7896-4342","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":null,"created_at":"2026-07-19T00:21:48.116752Z","pmid":"35119918","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}