{"doi":"10.1126/sciadv.abj1826","title":"Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies","abstract":". Both mechanisms may contribute to beneficial actions described for PrP-directed ligands and pave the way for new therapeutic strategies against currently incurable neurodegenerative diseases.","journal":"Science Advances","year":2021,"id":166997,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9603,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":693643,"name":"Behnam Mohammadi","orcid":"0000-0002-9178-3949","position":1,"is_corresponding":false},{"id":693644,"name":"Mohsin Shafiq","orcid":"0000-0002-4974-8955","position":2,"is_corresponding":false},{"id":300782,"name":"Karl Frontzek","orcid":"0000-0002-0945-8857","position":3,"is_corresponding":false},{"id":693645,"name":"Julia Bär","orcid":"0000-0002-0954-2776","position":4,"is_corresponding":false},{"id":693646,"name":"Amulya Nidhi Shrivastava","orcid":"0000-0002-1322-8018","position":5,"is_corresponding":false},{"id":693647,"name":"Markus Daμμe","orcid":"0000-0002-9699-9351","position":6,"is_corresponding":false},{"id":693648,"name":"Feizhi Song","orcid":"0009-0002-5144-5555","position":7,"is_corresponding":false},{"id":693649,"name":"Alexander Schwarz","orcid":"0000-0002-9700-9129","position":8,"is_corresponding":false},{"id":678334,"name":"Stefano Da Vela","orcid":"0000-0002-1700-4759","position":9,"is_corresponding":false},{"id":693650,"name":"Tania Massignan","orcid":"0000-0002-6176-2696","position":10,"is_corresponding":false},{"id":693651,"name":"Sebastian Jung","orcid":"0000-0002-0365-5710","position":11,"is_corresponding":false},{"id":693652,"name":"Angela da Silva Correia","orcid":"0000-0003-1903-7172","position":12,"is_corresponding":false},{"id":666778,"name":"Matthias Schmitz","orcid":"0000-0002-5502-681X","position":13,"is_corresponding":false},{"id":349952,"name":"Berta Puig","orcid":"0000-0002-2255-8393","position":14,"is_corresponding":false},{"id":688270,"name":"Simone Hornemann","orcid":"0000-0002-2674-9891","position":15,"is_corresponding":false},{"id":300800,"name":"Inga Zerr","orcid":"0000-0002-6722-2463","position":16,"is_corresponding":false},{"id":592083,"name":"Jörg Tatzelt","orcid":"0000-0001-5017-5528","position":17,"is_corresponding":false},{"id":572697,"name":"Emiliano Biasini","orcid":"0000-0002-3927-6341","position":18,"is_corresponding":false},{"id":263645,"name":"Paul Säftig","orcid":"0000-0003-2637-7052","position":19,"is_corresponding":false},{"id":229025,"name":"Michaela Schweizer","orcid":"0000-0001-5062-328X","position":20,"is_corresponding":false},{"id":257884,"name":"Dmitri I. Svergun","orcid":"0000-0003-0830-5696","position":21,"is_corresponding":false},{"id":661462,"name":"Ladan Amin","orcid":"0000-0001-6388-8869","position":22,"is_corresponding":false},{"id":629368,"name":"Federica Mazzola","orcid":null,"position":23,"is_corresponding":false},{"id":628160,"name":"Luca Varani","orcid":"0000-0002-0963-0987","position":24,"is_corresponding":false},{"id":694390,"name":"Simrika Thapa","orcid":null,"position":25,"is_corresponding":false},{"id":482668,"name":"Sabine Gilch","orcid":"0000-0001-5923-3464","position":26,"is_corresponding":false},{"id":693653,"name":"Hermann Schätzl","orcid":"0000-0003-4972-8740","position":27,"is_corresponding":false},{"id":353116,"name":"David A. Harris","orcid":"0000-0002-6985-5790","position":28,"is_corresponding":false},{"id":372137,"name":"Antoine Triller","orcid":"0000-0002-7530-1233","position":29,"is_corresponding":false},{"id":501710,"name":"Marina Mikhaylova","orcid":"0000-0001-7646-1346","position":30,"is_corresponding":false},{"id":300784,"name":"Adriano Aguzzi","orcid":"0000-0002-0344-6708","position":31,"is_corresponding":false},{"id":335163,"name":"Hermann C. Altmeppen","orcid":"0000-0001-9439-6533","position":32,"is_corresponding":false},{"id":335164,"name":"Markus Glatzel","orcid":"0000-0002-7720-8817","position":33,"is_corresponding":false},{"id":693642,"name":"Luise Linsenmeier","orcid":"0000-0002-4680-7622","position":0,"is_corresponding":true}],"reference_count":135,"raw_metadata":null,"created_at":"2026-07-18T23:45:54.042727Z","pmid":"34818048","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}