{"doi":"10.1126/sciadv.abj1604","title":"Exportin 1 modulates life span by regulating nucleolar dynamics via the autophagy protein LGG-1/GABARAP","abstract":"Altered nucleolar and ribosomal dynamics are key hallmarks of aging, but their regulation remains unclear. Building on the knowledge that the conserved nuclear export receptor Exportin 1 (XPO-1/XPO1) modulates proteostasis and life span, we systematically analyzed the impact of nuclear export on protein metabolism. Using transcriptomic and subcellular proteomic analyses in nematodes, we demonstrate that XPO-1 modulates the nucleocytoplasmic distribution of key proteins involved in nucleolar dynamics and ribosome function, including fibrillarin (FIB-1/FBL) and RPL-11 (RPL11). Silencing xpo-1 led to marked reduction in global translation, which was accompanied by decreased nucleolar size and lower fibrillarin levels. A targeted screen of known proteostatic mediators revealed that the autophagy protein LGG-1/GABARAP modulates nucleolar size by regulating RPL-11 levels, linking specific protein degradation to ribosome metabolism. Together, our study reveals that nucleolar size and life span are regulated by LGG-1/GABARAP via ribosome protein surveillance.","journal":"Science Advances","year":2022,"id":257348,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":485313,"name":"Taewook Kang","orcid":"0000-0003-3959-4777","position":1,"is_corresponding":false},{"id":907309,"name":"Tara G. Thakurta","orcid":"0000-0003-2742-9520","position":2,"is_corresponding":false},{"id":907775,"name":"Celeste Ng","orcid":null,"position":3,"is_corresponding":false},{"id":305868,"name":"Aric N. Rogers","orcid":"0000-0002-6149-6842","position":4,"is_corresponding":false},{"id":238142,"name":"Martin R. Larsen","orcid":"0000-0001-6203-0123","position":5,"is_corresponding":false},{"id":907310,"name":"Louis R. Lapierre","orcid":"0000-0002-8154-141X","position":6,"is_corresponding":false},{"id":907308,"name":"Anita Kumar","orcid":"0000-0002-8352-164X","position":0,"is_corresponding":true}],"reference_count":72,"raw_metadata":null,"created_at":"2026-07-19T00:25:30.183987Z","pmid":"35363528","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}