{"doi":"10.1126/sciadv.abg8306","title":"The ETS transcription factor ERF controls the exit from the naïve pluripotent state in a MAPK-dependent manner","abstract":"ESC remain trapped in an intermediate state of pluripotency with naïve-associated features. Elimination of the transcription factor ERF overcomes the developmental blockage of RAS-deficient cells by naïve enhancer decommissioning. Mechanistically, ERF regulates NANOG expression and ensures naïve pluripotency by strengthening naïve transcription factor binding at ESC enhancers. Moreover, ERF negatively regulates the expression of the methyltransferase DNMT3B, which participates in the extinction of the naïve transcriptional program. Collectively, we demonstrated an essential role for ERF controlling the exit from naïve pluripotency in a MAPK-dependent manner during the progression to primed pluripotency.","journal":"Science Advances","year":2021,"id":200478,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.96,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":293810,"name":"Teresa Olbrich","orcid":null,"position":1,"is_corresponding":false},{"id":95455,"name":"Desiree Tillo","orcid":"0000-0003-3568-6148","position":2,"is_corresponding":false},{"id":356751,"name":"Andy D. Tran","orcid":"0000-0002-2388-7121","position":3,"is_corresponding":false},{"id":654090,"name":"Catherine N. Domingo","orcid":null,"position":4,"is_corresponding":false},{"id":652928,"name":"Mariajose Franco","orcid":"0000-0002-9512-4086","position":5,"is_corresponding":false},{"id":52152,"name":"Peter Fitzgerald","orcid":"0000-0001-8769-0507","position":6,"is_corresponding":false},{"id":562251,"name":"Michael J. Kruhlak","orcid":"0000-0003-3976-6233","position":7,"is_corresponding":false},{"id":292712,"name":"Sergio Ruiz","orcid":"0000-0002-0177-6965","position":8,"is_corresponding":false},{"id":652926,"name":"María Vega-Sendino","orcid":"0000-0001-8179-6335","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-18T23:50:48.624274Z","pmid":"34597136","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}