{"doi":"10.1126/sciadv.abg6707","title":"Synchronous and opponent thermosensors use flexible cross-inhibition to orchestrate thermal homeostasis","abstract":"WCs and CCs detect temperature changes using overlapping combinations of ionotropic receptors: Ir68a, Ir93a, and Ir25a for WCs and Ir21a, Ir93a, and Ir25a for CCs. WCs mediate avoidance to warming while cross-inhibiting avoidance to cooling, and CCs mediate avoidance to cooling while cross-inhibiting avoidance to warming. Ambient temperature-dependent regulation of the strength of WC- and CC-mediated cross-inhibition keeps larvae near their homeostatic set point. Using neurophysiology, quantitative behavioral analysis, and connectomics, we demonstrate how flexible integration between warming and cooling pathways can orchestrate homeostatic thermoregulation.","journal":"Science Advances","year":2021,"id":157949,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":48,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9459,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":563654,"name":"Alicia Chen","orcid":"0000-0001-5521-8566","position":1,"is_corresponding":false},{"id":506035,"name":"Gonzalo Budelli","orcid":"0000-0002-2157-5511","position":2,"is_corresponding":false},{"id":667052,"name":"Matthew Berck","orcid":null,"position":3,"is_corresponding":false},{"id":563655,"name":"Vincent Richter","orcid":"0000-0001-8009-0357","position":4,"is_corresponding":false},{"id":563656,"name":"Anna Rist","orcid":"0000-0001-7634-1432","position":5,"is_corresponding":false},{"id":563657,"name":"Andreas S. Thum","orcid":"0000-0002-3830-6596","position":6,"is_corresponding":false},{"id":72580,"name":"Albert Cardona","orcid":"0000-0003-4941-6536","position":7,"is_corresponding":false},{"id":556227,"name":"Mason Klein","orcid":"0000-0001-8211-077X","position":8,"is_corresponding":false},{"id":563658,"name":"Paul Garrity","orcid":"0000-0002-8274-6564","position":9,"is_corresponding":false},{"id":233156,"name":"Aravinthan D. T. Samuel","orcid":"0000-0002-1672-8720","position":10,"is_corresponding":false},{"id":559178,"name":"Luis Hernandez-Nunez","orcid":"0000-0003-3102-9036","position":0,"is_corresponding":true}],"reference_count":72,"raw_metadata":null,"created_at":"2026-07-18T23:44:26.210708Z","pmid":"34452914","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}