{"doi":"10.1126/sciadv.abf3898","title":"The epigenetic factor FVE orchestrates cytoplasmic SGS3-DRB4-DCL4 activities to promote transgene silencing in <i>Arabidopsis</i>","abstract":"mutations substantially reduced the accumulation of transgene-derived small interfering RNAs (siRNAs). FVE interacts with suppressor of gene silencing 3 (SGS3), a master component in PTGS. FVE promotes SGS3 homodimerization that is essential for its function. FVE can bind to single-stranded RNA and double-stranded RNA (dsRNA) with moderate affinities, while its truncated form FVE-8 has a significantly increased binding affinity to dsRNA. These affinities affect the association and channeling of SGS3-RNA to downstream dsRNA binding protein 4 (DRB4)/Dicer-like protein 2/4 (DCL2/4) complexes. Hence, FVE, but not FVE-8, biochemically enhances the DRB4/DCL2/4 activity in vitro. We surmise that FVE promotes production of transgene-derived siRNAs through concertedly tuning SGS3-DRB4/DCL2/4 functions. Thus, this study revealed a noncanonical role of FVE in PTGS.","journal":"Science Advances","year":2021,"id":177610,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9599,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":722019,"name":"Yanjun Li","orcid":"0000-0003-3822-6470","position":1,"is_corresponding":false},{"id":537732,"name":"Zeyang Ma","orcid":"0000-0003-4373-8286","position":2,"is_corresponding":false},{"id":722020,"name":"Xingxing Yan","orcid":"0000-0002-0140-4029","position":3,"is_corresponding":false},{"id":722021,"name":"Niankui Li","orcid":"0009-0007-6277-9434","position":4,"is_corresponding":false},{"id":722022,"name":"Baoshuan Shang","orcid":"0000-0002-8744-3554","position":5,"is_corresponding":false},{"id":722605,"name":"Xiaomei Hu","orcid":null,"position":6,"is_corresponding":false},{"id":722023,"name":"Kai Cui","orcid":"0000-0003-3432-5957","position":7,"is_corresponding":false},{"id":98687,"name":"Hisashi Koiwa","orcid":"0000-0002-7421-340X","position":8,"is_corresponding":false},{"id":537733,"name":"Xiuren Zhang","orcid":"0000-0001-8982-2999","position":9,"is_corresponding":false},{"id":722018,"name":"Di Sun","orcid":"0000-0002-5857-0343","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-18T23:47:32.096934Z","pmid":"34348894","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}