{"doi":"10.1126/sciadv.abd2054","title":"KIF13A motors are regulated by Rab22A to function as weak dimers inside the cell","abstract":"Endocytic recycling is a complex itinerary, critical for many cellular processes. Membrane tubulation is a hallmark of recycling endosomes (REs), mediated by KIF13A, a kinesin-3 family motor. Understanding the regulatory mechanism of KIF13A in RE tubulation and cargo recycling is of fundamental importance but is overlooked. Here, we report a unique mechanism of KIF13A dimerization modulated by Rab22A, a small guanosine triphosphatase, during RE tubulation. A conserved proline between neck coil-coiled-coil (NC-CC1) domains of KIF13A creates steric hindrance, rendering the motors as inactive monomers. Rab22A plays an unusual role by binding to NC-CC1 domains of KIF13A, relieving proline-mediated inhibition and facilitating motor dimerization. As a result, KIF13A motors produce balanced motility and force against multiple dyneins in a molecular tug-of-war to regulate RE tubulation and homeostasis. Together, our findings demonstrate that KIF13A motors are tuned at a single-molecule level to function as weak dimers on the cellular cargo.","journal":"Science Advances","year":2021,"id":186309,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9587,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":744318,"name":"Meenakshi Sundaram Aravintha Siva","orcid":null,"position":1,"is_corresponding":false},{"id":744319,"name":"Ruchi Kumari","orcid":null,"position":2,"is_corresponding":false},{"id":743731,"name":"Dipeshwari J. Shewale","orcid":"0000-0001-5449-1878","position":3,"is_corresponding":false},{"id":424955,"name":"Ashim Rai","orcid":"0000-0002-4058-1773","position":4,"is_corresponding":false},{"id":425586,"name":"Michael Ritt","orcid":null,"position":5,"is_corresponding":false},{"id":743732,"name":"Prerna Sharma","orcid":"0000-0003-2969-0976","position":6,"is_corresponding":false},{"id":124156,"name":"Subba Rao Gangi Setty","orcid":"0000-0003-4035-2900","position":7,"is_corresponding":false},{"id":424957,"name":"Sivaraj Sivaramakrishnan","orcid":"0000-0002-9541-6994","position":8,"is_corresponding":false},{"id":744320,"name":"Virupakshi Soppina","orcid":null,"position":9,"is_corresponding":false},{"id":743730,"name":"Nishaben Patel","orcid":"0000-0003-4724-5710","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-18T23:48:42.632147Z","pmid":"33536208","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}