{"doi":"10.1126/sciadv.abc7885","title":"Acoustohydrodynamic tweezers via spatial arrangement of streaming vortices","abstract":"Acoustics-based tweezers provide a unique toolset for contactless, label-free, and precise manipulation of bioparticles and bioanalytes. Most acoustic tweezers rely on acoustic radiation forces; however, the accompanying acoustic streaming often generates unpredictable effects due to its nonlinear nature and high sensitivity to the three-dimensional boundary conditions. Here, we demonstrate acoustohydrodynamic tweezers, which generate stable, symmetric pairs of vortices to create hydrodynamic traps for object manipulation. These stable vortices enable predictable control of a flow field, which translates into controlled motion of droplets or particles on the operating surface. We built a programmable droplet-handling platform to demonstrate the basic functions of planar-omnidirectional droplet transport, merging droplets, and in situ mixing via a sequential cascade of biochemical reactions. Our acoustohydrodynamic tweezers enables improved control of acoustic streaming and demonstrates a previously unidentified method for contact-free manipulation of bioanalytes and digitalized liquid handling based on a compact and scalable functional unit.","journal":"Science Advances","year":2021,"id":156149,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":55,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9496,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":235104,"name":"Peiran Zhang","orcid":"0000-0002-3873-9949","position":1,"is_corresponding":false},{"id":307729,"name":"Zhanwei Zhong","orcid":"0000-0002-0946-574X","position":2,"is_corresponding":false},{"id":274161,"name":"Jianping Xia","orcid":"0000-0001-9902-0228","position":3,"is_corresponding":false},{"id":407336,"name":"Joseph Rich","orcid":"0000-0002-6249-2093","position":4,"is_corresponding":false},{"id":266324,"name":"D. John","orcid":"0000-0001-8001-9120","position":5,"is_corresponding":false},{"id":307727,"name":"Xingyu Su","orcid":"0000-0001-9764-0968","position":6,"is_corresponding":false},{"id":266321,"name":"Zhenhua Tian","orcid":"0000-0002-1903-5604","position":7,"is_corresponding":false},{"id":235105,"name":"Hunter Bachman","orcid":"0000-0002-2356-5392","position":8,"is_corresponding":false},{"id":275751,"name":"Joseph Rufo","orcid":"0000-0001-7408-2393","position":9,"is_corresponding":false},{"id":266327,"name":"Yuyang Gu","orcid":"0000-0002-6545-2521","position":10,"is_corresponding":false},{"id":457295,"name":"Putong Kang","orcid":"0000-0002-1762-1239","position":11,"is_corresponding":false},{"id":307731,"name":"Krishnendu Chakrabarty","orcid":"0000-0003-4475-6435","position":12,"is_corresponding":false},{"id":660139,"name":"Thomas P. Witelski","orcid":"0000-0003-0789-9859","position":13,"is_corresponding":false},{"id":235107,"name":"Tony Jun Huang","orcid":"0000-0003-1205-3313","position":14,"is_corresponding":false},{"id":307728,"name":"Haodong Zhu","orcid":"0000-0002-8661-2504","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-18T23:44:08.368845Z","pmid":"33523965","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}