{"doi":"10.1126/sciadv.abb3461","title":"Plasma-derived extracellular vesicle analysis and deconvolution enable prediction and tracking of melanoma checkpoint blockade outcome","abstract":"Immune checkpoint inhibitors (ICIs) show promise, but most patients do not respond. We identify and validate biomarkers from extracellular vesicles (EVs), allowing non-invasive monitoring of tumor- intrinsic and host immune status, as well as a prediction of ICI response. We undertook transcriptomic profiling of plasma-derived EVs and tumors from 50 patients with metastatic melanoma receiving ICI, and validated with an independent EV-only cohort of 30 patients. Plasma-derived EV and tumor transcriptomes correlate. EV profiles reveal drivers of ICI resistance and melanoma progression, exhibit differentially expressed genes/pathways, and correlate with clinical response to ICI. We created a Bayesian probabilistic deconvolution model to estimate contributions from tumor and non-tumor sources, enabling interpretation of differentially expressed genes/pathways. EV RNA-seq mutations also segregated ICI response. EVs serve as a non-invasive biomarker to jointly probe tumor-intrinsic and immune changes to ICI, function as predictive markers of ICI responsiveness, and monitor tumor persistence and immune activation.","journal":"Science Advances","year":2020,"id":2273,"datarank":2.034500583070378,"base_score":4.110873864173311,"endowment":4.110873864173311,"self_citation_contribution":0.6166310796259968,"citation_network_contribution":1.4178695034443816,"self_endowment_contribution":0.6166310796259968,"citer_contribution":1.4178695034443816,"corpus_percentile":null,"corpus_rank":null,"citation_count":60,"citer_count":56,"citers_with_citation_signal":50,"citers_with_endowment":50,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0595,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-11-13","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":17981,"name":"Gyulnara G. Kasumova","orcid":null,"position":1,"is_corresponding":false},{"id":15991,"name":"William A. Michaud","orcid":"0000-0002-3664-2094","position":2,"is_corresponding":false},{"id":17976,"name":"Jessica Cintolo-Gonzalez","orcid":"0000-0003-0572-5265","position":3,"is_corresponding":false},{"id":28322,"name":"Marta Díaz-Martínez","orcid":null,"position":4,"is_corresponding":false},{"id":28323,"name":"Jacqueline Ohmura","orcid":"0000-0002-5894-2493","position":5,"is_corresponding":false},{"id":396,"name":"Arnav Mehta","orcid":"0000-0002-0313-2848","position":6,"is_corresponding":false},{"id":17975,"name":"Isabel Chien","orcid":"0000-0001-7207-8526","position":7,"is_corresponding":false},{"id":399,"name":"Dennie T. Frederick","orcid":"0000-0003-3355-5267","position":8,"is_corresponding":false},{"id":28324,"name":"Sonia Cohen","orcid":"0000-0003-0172-5620","position":9,"is_corresponding":false},{"id":17978,"name":"Deborah Plana","orcid":"0000-0002-4218-1693","position":10,"is_corresponding":false},{"id":28325,"name":"Douglas Johnson","orcid":null,"position":11,"is_corresponding":false},{"id":410,"name":"Keith T. Flaherty","orcid":"0000-0002-3402-0478","position":12,"is_corresponding":false},{"id":412,"name":"Ryan J. Sullivan","orcid":"0000-0001-5344-6645","position":13,"is_corresponding":false},{"id":14693,"name":"Sharon L. R. Kardia","orcid":"0000-0002-9853-3379","position":14,"is_corresponding":false},{"id":411,"name":"Genevieve M. Boland","orcid":"0000-0002-7522-6173","position":15,"is_corresponding":false},{"id":28326,"name":"Marta Díaz‐Martínez","orcid":null,"position":16,"is_corresponding":false},{"id":28327,"name":"Douglas B. Johnson","orcid":"0000-0002-6390-773X","position":17,"is_corresponding":false},{"id":398,"name":"Alvin Shi","orcid":"0000-0002-6625-6792","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}