{"doi":"10.1126/sciadv.abb0737","title":"Plasma cells shape the mesenchymal identity of ovarian cancers through transfer of exosome-derived microRNAs","abstract":"Ovarian cancer represents a highly lethal disease that poses a substantial burden for females, with four main molecular subtypes carrying distinct clinical outcomes. Here, we demonstrated that plasma cells, a subset of antibody-producing B cells, were enriched in the mesenchymal subtype of high-grade serous ovarian cancers (HGSCs). Plasma cell abundance correlated with the density of mesenchymal cells in clinical specimens of HGSCs. Coculture of nonmesenchymal ovarian cancer cells and plasma cells induced a mesenchymal phenotype of tumor cells in vitro and in vivo. Phenotypic switch was mediated by the transfer of plasma cell-derived exosomes containing miR-330-3p into nonmesenchymal ovarian cancer cells. Exosome-derived miR-330-3p increased expression of junctional adhesion molecule B in a noncanonical fashion. Depletion of plasma cells by bortezomib reversed the mesenchymal characteristics of ovarian cancer and inhibited in vivo tumor growth. Collectively, our work suggests targeting plasma cells may be a novel approach for ovarian cancer therapy.","journal":"Science Advances","year":2021,"id":156281,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":55,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.953,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":660454,"name":"Wei Wang","orcid":"0000-0001-8388-0987","position":1,"is_corresponding":false},{"id":178193,"name":"Linjie Zhao","orcid":"0000-0002-3372-2873","position":2,"is_corresponding":false},{"id":279494,"name":"Xin Wang","orcid":"0000-0002-5122-2418","position":3,"is_corresponding":false},{"id":178168,"name":"Ryan C. Gimple","orcid":"0000-0002-7189-3243","position":4,"is_corresponding":false},{"id":660455,"name":"Lian Xu","orcid":"0000-0002-6374-7342","position":5,"is_corresponding":false},{"id":337043,"name":"Yuan Wang","orcid":"0000-0002-6324-6134","position":6,"is_corresponding":false},{"id":88695,"name":"Jeremy N. Rich","orcid":"0000-0001-7845-5302","position":7,"is_corresponding":false},{"id":178194,"name":"Shengtao Zhou","orcid":"0000-0001-8322-5536","position":8,"is_corresponding":false},{"id":178163,"name":"Zhengnan Yang","orcid":"0000-0003-1076-3530","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-18T23:44:08.368845Z","pmid":"33627414","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}