{"doi":"10.1126/sciadv.aba9950","title":"A novel cardiomyogenic role for Isl1 <sup>+</sup> neural crest cells in the inflow tract","abstract":"Most CPCs undergo programmed silencing during early cardiogenesis through proteasome-mediated and PRC2 (Polycomb group repressive complex 2)-mediated Isl1 repression, selectively in the outflow tract. A notable exception is a domain of cardiac neural crest cells (CNCs) in the inflow tract. These \"dorsal CNCs\" are regulated through a Wnt/β-catenin/Isl1 feedback loop and generate a limited number of trabecular cardiomyocytes that undergo multiple clonal divisions during compaction, to eventually produce ~10% of the biventricular myocardium. After birth, CNCs continue to generate cardiomyocytes that, however, exhibit diminished clonal amplification dynamics. Thus, although the postnatal heart sustains cardiomyocyte-producing CNCs, their regenerative potential is likely diminished by the loss of trabeculation-like proliferative properties.","journal":"Science Advances","year":2020,"id":77079,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9504,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":227347,"name":"Michael Durante","orcid":"0000-0003-3137-6847","position":1,"is_corresponding":false},{"id":403284,"name":"Krystalenia Valasaki","orcid":null,"position":2,"is_corresponding":false},{"id":401870,"name":"Amarylis Wanschel","orcid":"0000-0002-5603-7983","position":3,"is_corresponding":false},{"id":227353,"name":"J. William Harbour","orcid":"0000-0002-1104-9809","position":4,"is_corresponding":false},{"id":88819,"name":"Joshua M. Hare","orcid":"0000-0002-7751-5032","position":5,"is_corresponding":false},{"id":403283,"name":"Konstantinos E. Hatzistergos","orcid":null,"position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T21:48:50.085103Z","pmid":"33268364","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}