{"doi":"10.1126/sciadv.aba1606","title":"Suprachoroidal gene transfer with nonviral nanoparticles","abstract":"Subretinal injections of viral vectors provide great benefits but have limited cargo capacity; they induce innate and adaptive immune responses, which may cause damage and preclude repeated injections; and they pose administration risks. As a new biotechnology, suprachoroidal injections of biodegradable nanoparticles (NPs) containing a reporter plasmid induce reporter expression in rat photoreceptors and RPE throughout the entire eye and maintain expression for at least 8 months. Multiple injections markedly increase expression. Suprachoroidal injection of NPs containing a VEGF expression plasmid caused severe subretinal neovascularization progressing to subretinal fibrosis, similar to what occurs in untreated patients with neovascular age-related macular degeneration, providing a new model and proof of concept for level and duration of expression. Suprachoroidal injection of NPs containing a VEGF-binding protein expression plasmid significantly suppressed VEGF-induced vascular leakage and neovascularization demonstrating therapeutic potential. These data suggest that nonviral NP suprachoroidal gene transfer may provide a noninvasive, repeatable alternative to subretinal injection of viral vectors.","journal":"Science Advances","year":2020,"id":65209,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":61,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9554,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":344871,"name":"Jayoung Kim","orcid":"0000-0002-4883-2768","position":1,"is_corresponding":false},{"id":250494,"name":"Stephany Y. Tzeng","orcid":"0000-0002-7561-482X","position":2,"is_corresponding":false},{"id":344872,"name":"Kun Ding","orcid":"0000-0003-1098-5424","position":3,"is_corresponding":false},{"id":344873,"name":"Zibran Hafiz","orcid":"0000-0003-0955-2277","position":4,"is_corresponding":false},{"id":344874,"name":"Da Long","orcid":"0000-0002-2639-535X","position":5,"is_corresponding":false},{"id":336892,"name":"Jiangxia Wang","orcid":"0000-0002-1715-3981","position":6,"is_corresponding":false},{"id":239519,"name":"Jordan J. Green","orcid":"0000-0003-4176-3808","position":7,"is_corresponding":false},{"id":54565,"name":"Peter A. Campochiaro","orcid":"0000-0003-2531-8229","position":8,"is_corresponding":false},{"id":300843,"name":"Jikui Shen","orcid":"0000-0002-5262-5606","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T21:13:23.327603Z","pmid":"32937452","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}