{"doi":"10.1126/sciadv.aaz7809","title":"Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4 <sup>+</sup> T cells","abstract":"T cells were most potent by activating multiple transcriptional programs associated with enhanced antitumor function. We found sustained activation of cytotoxicity, costimulation, oxidative phosphorylation- and proliferation-related genes, and simultaneously reduced differentiation and exhaustion. Our study identifies molecular features of TCR8 expression that can guide the development of enhanced immunotherapies.","journal":"Science Advances","year":2020,"id":96586,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9439,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":478789,"name":"Gagan Bajwa","orcid":"0000-0001-8336-5635","position":1,"is_corresponding":false},{"id":478790,"name":"Benoît M. Carrères","orcid":"0000-0002-7532-7572","position":2,"is_corresponding":false},{"id":478791,"name":"Elisabeth Hoyer","orcid":"0000-0002-7042-2247","position":3,"is_corresponding":false},{"id":478792,"name":"Isabelle Gruber","orcid":"0000-0002-4871-9271","position":4,"is_corresponding":false},{"id":249834,"name":"Melisa Martinez-Paniagua","orcid":"0000-0002-7275-4317","position":5,"is_corresponding":false},{"id":324285,"name":"Yi-Ru Yu","orcid":"0000-0002-3562-3502","position":6,"is_corresponding":false},{"id":478793,"name":"Nazila Nouraee","orcid":"0000-0001-8560-1451","position":7,"is_corresponding":false},{"id":478794,"name":"Fatemeh Sadeghi","orcid":"0000-0001-5043-7823","position":8,"is_corresponding":false},{"id":239412,"name":"Meng‐Fen Wu","orcid":null,"position":9,"is_corresponding":false},{"id":368660,"name":"Tao Wang","orcid":"0000-0003-1957-7160","position":10,"is_corresponding":false},{"id":478795,"name":"Michaël Hebeisen","orcid":"0000-0003-3416-1112","position":11,"is_corresponding":false},{"id":478796,"name":"Nathalie Rufer","orcid":"0000-0002-9871-6271","position":12,"is_corresponding":false},{"id":18360,"name":"Navin Varadarajan","orcid":"0000-0001-7524-8228","position":13,"is_corresponding":false},{"id":109858,"name":"Ping‐Chih Ho","orcid":"0000-0003-3078-3774","position":14,"is_corresponding":false},{"id":3643,"name":"Malcolm K. Brenner","orcid":"0000-0002-3657-7675","position":15,"is_corresponding":false},{"id":226369,"name":"David Gfeller","orcid":"0000-0002-3952-0930","position":16,"is_corresponding":false},{"id":478797,"name":"Caroline Arber","orcid":"0000-0001-6440-9970","position":17,"is_corresponding":false},{"id":478788,"name":"Jan A. Rath","orcid":"0000-0001-8881-6060","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-18T22:35:06.014648Z","pmid":"32923584","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}