{"doi":"10.1126/sciadv.aaz1580","title":"Platelet P-selectin initiates cross-presentation and dendritic cell differentiation in blood monocytes","abstract":"Dendritic cells (DCs) are adept at cross-presentation and initiation of antigen-specific immunity. Clinically, however, DCs produced by in vitro differentiation of monocytes in the presence of exogenous cytokines have been met with limited success. We hypothesized that DCs produced in a physiological manner may be more effective and found that platelets activate a cross-presentation program in peripheral blood monocytes with rapid (18 hours) maturation into physiological DCs (phDCs). Differentiation of monocytes into phDCs was concomitant with the formation of an \"adhesion synapse,\" a biophysical junction enriched with platelet P-selectin and monocyte P-selectin glycoprotein ligand 1, followed by intracellular calcium fluxing and nuclear localization of nuclear factor κB. phDCs were more efficient than cytokine-derived DCs in generating tumor-specific T cell immunity. Our findings demonstrate that platelets mediate a cytokine-independent, physiologic maturation of DC and suggest a novel strategy for DC-based immunotherapies.","journal":"Science Advances","year":2020,"id":57436,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":78,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9549,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":299625,"name":"Douglas Hanlon","orcid":"0000-0003-4386-7491","position":1,"is_corresponding":false},{"id":299626,"name":"Najla Arshad","orcid":"0000-0001-5553-311X","position":2,"is_corresponding":false},{"id":299627,"name":"Jung Seok Lee","orcid":"0000-0002-9810-8647","position":3,"is_corresponding":false},{"id":299628,"name":"Kazuki Tatsuno","orcid":"0009-0009-5230-6136","position":4,"is_corresponding":false},{"id":300564,"name":"Alp Yurter","orcid":null,"position":5,"is_corresponding":false},{"id":299629,"name":"Eve Robinson","orcid":"0000-0002-3457-0090","position":6,"is_corresponding":false},{"id":110485,"name":"Renata B. Filler","orcid":"0000-0001-8579-8418","position":7,"is_corresponding":false},{"id":300565,"name":"Olga Sobolev","orcid":null,"position":8,"is_corresponding":false},{"id":300566,"name":"Christine M. Cote","orcid":null,"position":9,"is_corresponding":false},{"id":299630,"name":"Félix Rivera-Molina","orcid":"0000-0003-3772-497X","position":10,"is_corresponding":false},{"id":299631,"name":"Derek Toomre","orcid":"0000-0002-6827-8127","position":11,"is_corresponding":false},{"id":299632,"name":"Tarek M. Fahmy","orcid":"0000-0001-8740-4179","position":12,"is_corresponding":false},{"id":299633,"name":"Richard L. Edelson","orcid":"0000-0002-1552-2480","position":13,"is_corresponding":false},{"id":299624,"name":"Patrick Han","orcid":"0000-0002-0370-0729","position":0,"is_corresponding":true}],"reference_count":77,"raw_metadata":null,"created_at":"2026-07-18T21:06:31.136481Z","pmid":"32195350","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}