{"doi":"10.1126/sciadv.aay0922","title":"DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP","abstract":"The repair of DNA double-strand breaks occurs through nonhomologous end joining or homologous recombination in vertebrate cells-a choice that is thought to be decided by a competition between DNA-dependent protein kinase (DNA-PK) and the Mre11/Rad50/Nbs1 (MRN) complex but is not well understood. Using ensemble biochemistry and single-molecule approaches, here, we show that the MRN complex is dependent on DNA-PK and phosphorylated CtIP to perform efficient processing and resection of DNA ends in physiological conditions, thus eliminating the competition model. Endonucleolytic removal of DNA-PK-bound DNA ends is also observed at double-strand break sites in human cells. The involvement of DNA-PK in MRN-mediated end processing promotes an efficient and sequential transition from nonhomologous end joining to homologous recombination by facilitating DNA-PK removal.","journal":"Science Advances","year":2020,"id":51626,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":151,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9565,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":258483,"name":"Logan R. Myler","orcid":"0000-0003-0673-7049","position":1,"is_corresponding":false},{"id":258484,"name":"Michael M. Soniat","orcid":"0000-0003-3670-4344","position":2,"is_corresponding":false},{"id":261053,"name":"Nodar Makharashvili","orcid":null,"position":3,"is_corresponding":false},{"id":258485,"name":"Linda Lee","orcid":"0000-0002-4744-7243","position":4,"is_corresponding":false},{"id":258486,"name":"Susan P. Lees‐Miller","orcid":"0000-0001-5809-2516","position":5,"is_corresponding":false},{"id":105935,"name":"Ilya J. Finkelstein","orcid":"0000-0002-9371-2431","position":6,"is_corresponding":false},{"id":258487,"name":"Tanya T. Paull","orcid":"0000-0002-2991-651X","position":7,"is_corresponding":false},{"id":258482,"name":"Rajashree A. Deshpande","orcid":"0000-0001-5728-716X","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-18T20:41:30.009880Z","pmid":"31934630","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}