{"doi":"10.1124/dmd.31.1.7","title":"Constitutive Androstane Receptor and Pregnane X Receptor Gene Expression in Human Liver: Interindividual Variability and Correlation with CYP2B6 mRNA Levels","abstract":null,"journal":"Drug Metabolism and Disposition","year":2003,"id":685504,"datarank":0.6937459219926407,"base_score":4.624972813284271,"endowment":4.624972813284271,"self_citation_contribution":0.6937459219926407,"citation_network_contribution":0.0,"self_endowment_contribution":0.6937459219926407,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":101,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1790975,"name":"Stelvio M. Bandiera","orcid":null,"position":1,"is_corresponding":false},{"id":1395657,"name":"Jie Chen","orcid":"0000-0002-8742-1048","position":2,"is_corresponding":false},{"id":1783829,"name":"Thomas K.H. Chang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Constitutive Androstane Receptor and Pregnane X Receptor Gene Expression in Human Liver: Interindividual Variability and Correlation with CYP2B6 mRNA Levels","abstract":"The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) mediate the expression of mammalian cytochrome p450 (p450) 2B genes, including CYP2B6 in humans. Large interindividual differences exist in hepatic CYP2B6 expression, but the molecular basis for this variability is not well understood. In the present study, we developed real-time polymerase chain reaction methods to measure CYP2B6, CAR, and PXR mRNA expression and compared the levels in a panel of 12 individual human liver samples. The transcripts of CAR and CYP2B6 were present in all the samples analyzed, whereas those of PXR were detectable in all but one sample. A striking finding was the 240-fold interindividual variability in hepatic CAR mRNA levels, which was similar to the variability (278-fold) in CYP2B6 mRNA levels but greater than the 27-fold variability in PXR mRNA expression. Additional analysis revealed positive and statistically significant correlations between the mRNA levels of CAR and CYP2B6 (r(2) = 0.63, p = 0.002), PXR and CYP2B6 (r(2) = 0.75. p < 0.001), and CAR and PXR (r(2) = 0.86, p < 0.001). In summary, substantial interindividual differences exist in hepatic CAR and, to a lesser extent, PXR gene expression. The variability in the abundance of these transcription factors may contribute to the large interindividual differences in CYP2B6 gene expression in human liver.","is_dataset_classified":null,"base_score":4.624972813284271,"endowment":4.624972813284271,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12485946","pmcid":null,"openalex_id":"https://openalex.org/W2168103670","authors":[],"funders":[],"total_grants":0,"fwci":11.5343,"citation_percentile":0.98601399,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":5},{"year":2014,"count":6},{"year":2015,"count":4},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":5},{"year":2023,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0090955624025856?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0090955624025856?httpAccept=text/plain","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1124/dmd.31.1.7","host_type":"publisher"},{"url":"https://doi.org/10.1124/dmd.31.1.7","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12485946","host_type":"repository"}],"fields_of_study":["Pharmacogenetics and Drug Metabolism","Hormonal Regulation and Hypertension","Eicosanoids and Hypertension Pharmacology","Aryl Hydrocarbon Hydroxylases","Constitutive Androstane Receptor","Cytochrome P-450 CYP2B6","Gene Expression Regulation","Genetic Variation","Humans","Liver","Oxidoreductases, N-Demethylating","Pregnane X Receptor","RNA, Messenger","Receptors, Cytoplasmic and Nuclear","Receptors, Steroid","Transcription Factors"],"mesh_terms":["Pregnane X Receptor","Constitutive Androstane Receptor","Aryl Hydrocarbon Hydroxylases","Gene Expression Regulation","Humans","Liver","Oxidoreductases, N-Demethylating","Receptors, Steroid","RNA, Messenger","Transcription Factors","Genetic Variation","Receptors, Cytoplasmic and Nuclear","Cytochrome P-450 CYP2B6"],"keywords":["Pregnane X receptor","Constitutive androstane receptor","CYP2B6","Biology","Cytochrome P450","Messenger RNA","Gene expression","Receptor","CYP3A4","Gene","Nuclear receptor","Endocrinology","Internal medicine","Molecular biology","Transcription factor","Genetics","Metabolism","Medicine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T16:50:38.009288Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}