{"doi":"10.1124/dmd.114.062034","title":"Meta-Analysis of Expression of Hepatic Organic Anion–Transporting Polypeptide (OATP) Transporters in Cellular Systems Relative to Human Liver Tissue","abstract":null,"journal":"Drug Metabolism and Disposition","year":2015,"id":615477,"datarank":0.6749714505495399,"base_score":4.499809670330265,"endowment":4.499809670330265,"self_citation_contribution":0.6749714505495399,"citation_network_contribution":0.0,"self_endowment_contribution":0.6749714505495399,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":89,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1055880,"name":"Brahim Achour","orcid":"0000-0002-2595-5626","position":1,"is_corresponding":false},{"id":1586425,"name":"Amin Rostami-Hodjegan","orcid":null,"position":2,"is_corresponding":false},{"id":1586426,"name":"Aleksandra Galetin","orcid":null,"position":3,"is_corresponding":false},{"id":1586423,"name":"Justine Badée","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Meta-Analysis of Expression of Hepatic Organic Anion–Transporting Polypeptide (OATP) Transporters in Cellular Systems Relative to Human Liver Tissue","abstract":"Organic anion-transporting polypeptide (OATP)1B1, OATP1B3, and OATP2B1 transporters play an important role in hepatic drug disposition. Recently, an increasing number of studies have reported proteomic expression data for OATP transporters. However, systematic analysis and understanding of the actual differences in OATP expression between liver tissue and commonly used cellular systems is lacking. In the current study, meta-analysis was performed to assess the protein expression of OATP transporters reported in hepatocytes relative to liver tissue and to identify any potential correlations in transporter expression levels in the same individual. OATP1B1 was identified as the most abundant uptake transporter at 5.9 ± 8.3, 5.8 ± 3.3, and 4.2 ± 1.7 fmol/μg protein in liver tissue, sandwich-cultured human hepatocytes (SCHH), and cryopreserved suspended hepatocytes, respectively. The rank order in average expression in liver tissue and cellular systems was OATP1B1 > OATP1B3 ≈ OATP2B1. Abundance levels of the OATP transporters investigated were not significantly different between liver and cellular systems, with the exception of OATP2B1 expression in SCHH relative to liver tissue. Analysis of OATP1B1, OATP1B3, and OATP2B1 liver expression data in the same individuals (n = 86) identified weak (OATP1B1-OATP2B1) to moderately (OATP1B3-OATP2B1) significant correlations. A significant weak correlation was noted between OATP1B1 abundance and age of human donors, whereas expression of the OATPs investigated was independent of sex. Implications of the current analysis on the in vitro-in vivo extrapolation of transporter-mediated drug disposition using physiologically based pharmacokinetic models are discussed.","is_dataset_classified":null,"base_score":4.499809670330265,"endowment":4.499809670330265,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25564656","pmcid":null,"openalex_id":"https://openalex.org/W2117675164","authors":[],"funders":[{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"BB/K501256/1","title":null}],"total_grants":1,"fwci":2.4381,"citation_percentile":0.89891697,"influential_citations":5,"citation_trend":[{"year":2015,"count":3},{"year":2016,"count":10},{"year":2017,"count":14},{"year":2018,"count":10},{"year":2019,"count":9},{"year":2020,"count":9},{"year":2021,"count":6},{"year":2022,"count":6},{"year":2023,"count":9},{"year":2024,"count":8},{"year":2025,"count":5}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"http://dmd.aspetjournals.org/content/dmd/43/4/424.full.pdf","host_type":"BRONZE"},{"url":"https://api.elsevier.com/content/article/PII:S0090955624102711?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0090955624102711?httpAccept=text/plain","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1124/dmd.114.062034","host_type":"publisher"},{"url":"https://doi.org/10.1124/dmd.114.062034","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25564656","host_type":"repository"},{"url":"https://research.manchester.ac.uk/en/publications/4f80a4f5-6379-4fa9-adbe-0eb1a73b93e2","host_type":"repository"}],"fields_of_study":["Drug Transport and Resistance Mechanisms","Liver Disease Diagnosis and Treatment","Pharmacological Effects and Toxicity Studies","Biology","Medicine"],"mesh_terms":["Solute Carrier Organic Anion Transporter Family Member 1B3","Aging","Data Interpretation, Statistical","Pharmaceutical Preparations","Humans","Liver","Tissue Distribution","Cell Culture Techniques","Hepatocytes","Organic Anion Transporters","Liver-Specific Organic Anion Transporter 1","Organic Anion Transporters, Sodium-Independent","Proteomics"],"keywords":["Organic anion-transporting polypeptide","Organic anion transporter 1","Transporter","Organic cation transport proteins","Chemistry","Biochemistry","Gene expression","Biology","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T20:08:14.860475Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}