{"doi":"10.1117/12.3047209","title":"Semisupervised semantic segmentation of cell nuclei with diffusion model","abstract":"Accurate segmentation of cell nuclei in microscopic images is important for disease diagnosis and tissue microenvironment analysis. Supervised methods have shown promise but need large annotated datasets. Semi-supervised strategies help by incorporating unlabeled data, though performance can remain limited when labeled data are scarce. We propose a diffusion model-based semi-supervised framework that can use diverse unlabeled data in an unsupervised manner. Our method, called DTSeg, employs a latent diffusion model (LDM) and a transformer-based decoder. The LDM learns from varied unlabeled images, while the decoder is trained in a supervised manner with limited labeled data. Experiments on three datasets show that our method achieves better segmentation performance than existing semi-supervised approaches.","journal":null,"year":2025,"id":564064,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9492,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1236120,"name":"Sourya Sengupta","orcid":"0000-0003-1797-7072","position":1,"is_corresponding":false},{"id":298431,"name":"Mark A. Anastasio","orcid":"0000-0002-3192-4172","position":2,"is_corresponding":false},{"id":404861,"name":"Hua Li","orcid":"0000-0002-5629-2247","position":3,"is_corresponding":false},{"id":1466853,"name":"Zhuchen Shao","orcid":"0000-0002-9554-8831","position":0,"is_corresponding":true}],"reference_count":10,"raw_metadata":null,"created_at":"2026-07-19T02:56:17.117043Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}