{"doi":"10.1117/12.3001848","title":"Early detection of cutaneous neurofibromas using spatial frequency domain imaging and optical coherence tomography","abstract":"Cutaneous neurofibromas (cNF) appear commonly in neurofibromatosis type I (NF1) patients. cNFs usually appear in the skin at puberty and proliferate with increasing numbers and sizes throughout life. If cNFs can be detected and treated in their nascent stage, patient’s quality of life can be improved. To detect early-stage cNF, we have employed spatial frequency domain imaging (SFDI) and optical coherence tomography (OCT). SFDI has been applied to screen large skin areas on eleven cNF subjects. Suspect lesions invisible to the unaided eye but detected using SFDI were imaged with OCT to observe lesion microstructure. Three lesions were biopsied to compare with SFDI and OCT images. Suspect nascent cNFs which are invisible to the unaided eye were detected as low optical scattering regions in all patients. Large area screening using SFDI confirmed scattering contrast between the suspect nascent cNF and the surrounding uninvolved skin. Abnormal disc-shaped structures with reduced scattering regions detected by SFDI were also observed in OCT cross-sections.","journal":"eScholarship (California Digital Library)","year":2024,"id":493674,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9648,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":517452,"name":"Wangcun Jia","orcid":"0000-0002-5021-3827","position":1,"is_corresponding":false},{"id":504972,"name":"Gordon T. Kennedy","orcid":"0000-0002-2335-8887","position":2,"is_corresponding":false},{"id":559037,"name":"Nitesh Katta","orcid":"0000-0001-8097-5489","position":3,"is_corresponding":false},{"id":886202,"name":"Rafael J. Sierra","orcid":"0000-0002-8513-1477","position":4,"is_corresponding":false},{"id":1340091,"name":"James E. Johnson","orcid":"0000-0002-6777-8357","position":5,"is_corresponding":false},{"id":369400,"name":"Kristen M. Kelly","orcid":"0000-0002-5988-2197","position":6,"is_corresponding":false},{"id":504974,"name":"Anthony J. Durkin","orcid":"0000-0001-9124-6388","position":7,"is_corresponding":false},{"id":790973,"name":"J. Stuart Nelson","orcid":"0000-0002-2697-9152","position":8,"is_corresponding":false},{"id":559852,"name":"Thomas E. Milner","orcid":null,"position":9,"is_corresponding":false},{"id":1340090,"name":"Junsoo Lee","orcid":"0000-0001-8146-6862","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:09:03.883685Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}